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  1. So just switched meds. Pdoc had me on 400mg of seroquil... Which I loved. It was helping with sleep and mood was wonderful. But my cholesterol was through the bloody roof! Cardio said it was the highest cholesterol and triglyceride level she had EVER seen! My total was 474 and my tri was 622!!! She put me on crestor (which is awful btw... the swelling in my legs is soo painful). So pdoc, hubby and I decided it was time to try something new. She suggested Latuda, 60 mg, and I suggested Topamax as an add on, as I have done well on that in the past, and as an added benefit, migraine help, and possible weight loss! (I gained about 45 lbs with the Seroquil) Anyways, I took my first Latuda yesterday. At first I felt a bit sleepy. Then the jitters started. I am boucing my legs 24/7 it feels like. I took a klonopin, and then later had a 1/2 a glass of wine to see if I could calm down, but only helped a touch. Is there anything I can do to combat the jitters? Will it wear off in a couple weeks? I really need this to work. I have really run out of options on meds. My moods are very med resistant. Thanks for any advice you can give! Current meds: Latuda 60mg, Topamax 100mg, Ambien 10mg, Metoprolol 100mg, Wellbutrin 75mg, Crestor 5mg, Melatonin 5 mg, Valerian 1000mg, Protonix 40mg, Klonipin PRN, Imitrex PRN, Zofran PRN, Ventolin PRN
  2. I am dealing with UNREAL agitation, restlessness, jitteriness and anxiety that will not allow me to sit still, sleep or rest. It is absolutely relentless and I have never felt anything like this before. It's definitely more than just my regular anxiety. I wake up with it and it lasts all day. I have recently added a second antidepressant (Viibryd) to my regular AD (Pristiq) to pull me out of a slump I have been in for the past 3-4 months. It has helped with the depression but I'm still crying on a regular basis due to the intense agitation/restlessness so I'm not sure if I'd call it a win yet. I have tried almost all of the major anti-psychotics (risperidal, geodon, saphris, zyprexa, trazadone, seroquel) out there over the past 3 months and nothing is working. I have been on benzodiazipines for years off and on (mainly klonopin) and now my doctor is really trying to stay away from them due to their high potential to become addicting and also because the klonopin really wasn't working anymore and I was definitely building up tolerance/needing more and more to get the same effect. My doctor is now trying medications with off label uses to treat anxiety (gabapentin/lyrica) but they don't seem to be working either. I also take Topomax for migraine headaches and it has been an absolute God send. I've been on it now for 3 months. I would much rather be dealing with depression than this overwhelming jitteryness/agitation. I just want to be able to sit in a quiet room without wanting to rip my own skin off and gouge out my eyes. I can tell my doctor is at the end of his rope as well and isn't quite sure what to do with me. I've even looked into possible serotonin syndrome due to the added AD + tripitan medication (maxalt) + trazadone however I do not have muscle rigidity, fever, confusion, etc. although my pulse and BP are up (VERY vague symptoms). I'm just grasping at straws now. Desperetely searching for some kind of answer to end this suffering! I have an appointment to see my pdoc next week but I don't know what else he can prescribe. It seems like we have tried just about everything and are running out of options. If anyone has any sort of insight into this or any sort of suggestions it is much appreciated.
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