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Not sure if this is the right area for this but just thought I'd try here. Does anyone know how a medication like Risperidone works for bipolar? Is it more the Dopamine receptor antagonist or is it the 5-ht2a antagonist, that works for controlling bipolar disorder? I know there are other antagonists for the serotonin receptors but the 5-ht2a seems to come up a lot. One of the reasons I ask is because I was put on Risperidone and cymbalta (while in a psych hospital) and being diagnosed supposedly with bipolar/mixed state.(Even though I feel depressed alll the time) Straight SSRI/SNRI medications alone tend to give me a somewhat agitated euphoric feeling when I would yawn...not sure why, and its tough to explain. I don't feel good off of any SSRI's alone that I have tried and would just leave me the same... more Anxious and depressed. I didn't stay on that combo long because I landed in the ER because I couldn't settle down at night to sleep (literally flipping around in my bed)and cause my heart wouldn't stop racing.(my guess from the norepinephrine). While I did notice positive things from it in the beginning like I felt better about myself and wanted to socialize more, which is strange for never feeling like that ever. Anyways, if I was diagnosed bipolar why would a doctor stick me on an SNRI while on a medication that should control it alone like RIsperidone? Wouldn't that just in turn make me manic from all the extra serotonin? It just doesn't make any sense to me. That's what had me confused on which serotonin receptor is at work to stop manic episodes, and level you out. With the new psych doctor Im seeing, I don't have a full diagnosis yet, but was put on Seroquel XR at 50mg, and guess work my way up. The mental health person who did my partial diagnosis(before being able to see my new psychiatrist) said that it was more towards major depression/social anxiety disorder though. I had the genetic test done from 'genomind' to try to find a medication that wouldn't give me so many issues. (been on about 14 so far) My old doctor had called them and they recommended that but I was afraid to keep taking a AP due to the side effects. No I have accepted it and giving it another try. Still dont feel anything from it but I figure cause Im not upto the target dosage. The new doctor is trying to get a hold of the company to see what other medications might help. So, if anyone who understands this better, please feel free to explain how this med combo works, and all the receptor stuff. Sorry for rambling on as well.
Hi all - Wanted to reach out to you all, as I know this forum is full of incredibly bright and insightful people, to see if there may be any knowledge of Latuda's (or any AAP's) mechanism of action at the Alpha 2a (a2a) adrenergic receptor. I ask because: I currently take Intuniv, a post-synaptic Alpha 2a agonist. Latuda is listed simply as an Alpha 2a antagonist. What I'm wondering is whether this is pre- or post-synaptic, and will it ruin the effects I get from Intuniv? I don't want to take a med that directly hinders the action of another. laad