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  1. https://en.wikipedia.org/wiki/Amitriptyline https://en.wikipedia.org/wiki/Nortriptyline Both are quite similar, and that is no surprise, given that Notrtiptyline is Amitriptyline's major metabolite. When comparing both, we can ascertain the following: Amitriptyline has somewhat more SERT blocking going on, so might be slightly more "serotonergic" than Nortriptyline, although I am not quite sure if clinically relevant. Both are equally strong NRIs and 5HT2 antagonists. Amitriptyline is a stronger ALPHA1 blocker compared to Nortriptyline, so might cause more postural hypotension. Amitrptyline is a stronger antihistamine than Nortriptyline, so might cause more sedation and appetite. Amitriptyline is a stronger anticholinergic than Nortriptyline, so will probably cause more side effects. (Although stronger sedative and anticholinergic properties might be welcome, depending on the condition) What I am interested in: Who's been on both and how did they compare? (not only theoretically, but practically) binding affinities: picture source: https://abload.de/img/nortgpk1f.png
  2. As far as I am informed you need stimulants for treatment of ADHD. Most commonly used are Methylphenidate and Atomoxetine. Sometimes stuff like Bupropion is applied. But what about classic antidepressants with stimulant (NRI) properties? Let's say Desipramine or Nortriptyline, Reboxetine!? Can they help to some degree?
  3. Sertraline standalone makes many people somewhat apathetic, indifferent and unmotivated, and that's why doctor Gillman suggests augmenting it with Nortriptyline OR alternatively taking Clomipramine standalone for the full SNRI effect... Did anyone here try both combos? I am getting back on antidepressants and not sure how to proceed... but if I had to choose, I would preferably go for one of the two possibilities.
  4. It's been a long time since I've been back on the forums but here I am. I've been taking nortriptyline for over a month now and I'm at 200 mg. They originally put me on a low dose for headaches but my pdoc didn't think it would work well with the effexor I was taking and bumped up the dose and eased me off the effexor. I feel like I'm losing my mind in that I forget things pretty much instantly like leaving my purse in the cart at the store and not realizing it until I drove home. Or like where I put whatever I just had in my hands. My thoughts are all haywire and I'm not usually like this. I usually have an almost photographic memory and yesterday I actually turned to go down a one-way the wrong way in a small town I've lived in for years. I FORGOT TO TELL MY PDOC AT MY APPOINTMENT THAT I FORGET EVERYTHING! I called before the weekend but now I have to wait to hear back and my appointment isn't for a few weeks. Anyone else out there struggling like this? How are you coping? I should also include that I am unbelievably depressed so this just brings me down lower. I'm actually getting a little scared that I may have to go IP for the first time in over a year.
  5. Hello forum, I've had long term problems with treatment-resistant depression and also - in the last 3 or 4 years - have suffered from vertigo, migraines and stomach cramps. I have been taking 40mg fluoxetine daily which doesn't do much at all - makes me slightly less irritable, give me some very strange & vivid dreams, but not much else. Doctor has just given me some nortriptyline to take alongside the fluoxetine as a combination therapy. Initial dose 25mg and then increase to 50mg after 10 days. I started with the 25mg of nortriptyline 4 days ago and it has hit me quite hard. I felt very drowsy at first although this has eased a little now. Sleeping a lot too - possibly not a bad thing because my sleep quality isn't great. Feel "stoned" but not necessarily in a good way. On the other hand, no vertigo, no migraines, no stomach cramps and my mood is ok (albeit in a daze). I read something about fluoxetine interacting with TCAs like nortriptyline - something to do with liver enzymes that I don't understand - the upshot of it all was that one should be careful with TCA dosages because fluoxetine makes the TCA hang around in the system longer, as if it were a bigger dose than it actually is. Doctor has talked about gradually getting the nortriptyline dosage up to 75mg - 100mg in due course. But I don't know on reflection how familiar he is with this drug (especially in combination with fluoxetine) - he is following the guidance of a psychiatrist who assessed me, but I don't think the psychiatrist gave any advice on suitable dosages. Also the doctor said it's ok to drink alcohol in moderation when taking nortriptyline , which contradicts what I've read elsewhere (I don't plan to drink btw). I'm a bit concerned...should I be, do you think? (I would ask the doctor myself but it can take 3 weeks to get an appointment with him!) Thanks, A.
  6. Well I'll start off saying this is my first post ever... so if I'm doing stuff wrong then TS However, my question is regarding Pamelor (nortriptyline - generic name). It is also listed as Aventyl but I've never heard that name. I just started this drug two days ago, and I'm already having a few irritating side effects. I'm having a lot of dizziness, but despiate that my hands are "weak" numb and un coordinated. I noticed this extremely because I work at a desk for my job. Well I was looking this up online & I know it's one of the side effects...but does the feelings in my hands go away? I know when I was on the topamax it caused a tingling (like your extremities were asleep) but it went away w/ increased usage. My second question is I found a study online by the FDA, that said the numbness and tingling is caused by taking otc vitamin supplements with the Pamelor, in which I take Vitamin B complex and Vitamin D. I also drink a vitamin filled protein drink every morning. I wanted to know if anyone has stopped taking the vitamin and it fixed the problem (b/c blantely this fn sucks). But on the other side, I have mood rate disorders, including extreme anixety, depression, ADHD & ADD. It does seem to be helping these...as I was able to concentrate much better at work than before (due to my ADHD I'm rarley ever able to concentrate). Thanks so much.
  7. I've had various stomach problems since I went back on lithium, and the problems have increased with each additional med. Mostly, everything is much better now, but I have to make sure to take my nightime meds with food and/or milk or I end up having a very acidic stomach. Sometimes, it gets so acidic, I can feel it kind of sloshing up my esophagus (or I imagine it is) and the pain is almost unbearable. The upper part of my stomach burns and contracts like crazy, and the aforementioned sloshing feeling happens with each contraction. For the next day or two, it all feels burnt inside, and my stomach feels kind of full, like I ate a lot (even if I haven't eaten). It hurts when I eat. Ugh. It's really horrible, and it makes tossing back that hand full of pills kind of scary, since this happens sometimes even if I eat with the meds. It also makes me feel sorry for myself, which is so frickin' lame-o. My pdoc told me I need to see my gdoc, to make sure it's not gastric reflux or something else, because apparently it can cause scarring of the gastroesophageal junction (yay anatomy class). Gah. It's always something. Anyway, I am seeing my gdoc on Monday, but I'm hoping you all might have some ideas about juggling med cocktails with gastric cocktails. BTW, I love Adderall. I've been meaning to post about this since last summer, but it took getting a little brain organization before I finally did it.
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