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This question has been bugging me for quite a while but I'm not sure if anybody knows the answer. One of the treatments of bipolar depression is OFC (olanzapine-fluoxetine combination). I'm wondering why fluoxetine is often not recommended in the treatment of bipolar depression, even when used with a mood stabilizer and it is OK to used as part of OFC? And why can other antipsychotics not be used in combination with fluoxetine? What is so important or special about olanzapine that it is the only antipsychotic indicated, alongside fluoxetine, for the treatment of bipolar depression. Why can't ability, risperdal, geodon, seroquel etc be used. For example AFC ( aripiprazole-fluoxetine combination ). I take seroquel and fluoxetine and this sorted my depression Any thoughts??