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Found 3 results

  1. https://en.wikipedia.org/wiki/Amitriptyline https://en.wikipedia.org/wiki/Nortriptyline Both are quite similar, and that is no surprise, given that Notrtiptyline is Amitriptyline's major metabolite. When comparing both, we can ascertain the following: Amitriptyline has somewhat more SERT blocking going on, so might be slightly more "serotonergic" than Nortriptyline, although I am not quite sure if clinically relevant. Both are equally strong NRIs and 5HT2 antagonists. Amitriptyline is a stronger ALPHA1 blocker compared to Nortriptyline, so might cause more postural hypotension. Amitrptyline is a stronger antihistamine than Nortriptyline, so might cause more sedation and appetite. Amitriptyline is a stronger anticholinergic than Nortriptyline, so will probably cause more side effects. (Although stronger sedative and anticholinergic properties might be welcome, depending on the condition) What I am interested in: Who's been on both and how did they compare? (not only theoretically, but practically) binding affinities: picture source: https://abload.de/img/nortgpk1f.png
  2. Now that I have been on this cocktail for two weeks, I am noticing a new reality. I want to be more outgoing, I am alot calmer and want to socialize more. The downside is that I lack good social skills and the consequences scare me. I would be laying vulnerable and not knowing how to protect myself. Can I handle the changes with the new me? The old me, heck, I knew what to expect and how to handle this.
  3. It's been a long time since I've been back on the forums but here I am. I've been taking nortriptyline for over a month now and I'm at 200 mg. They originally put me on a low dose for headaches but my pdoc didn't think it would work well with the effexor I was taking and bumped up the dose and eased me off the effexor. I feel like I'm losing my mind in that I forget things pretty much instantly like leaving my purse in the cart at the store and not realizing it until I drove home. Or like where I put whatever I just had in my hands. My thoughts are all haywire and I'm not usually like this. I usually have an almost photographic memory and yesterday I actually turned to go down a one-way the wrong way in a small town I've lived in for years. I FORGOT TO TELL MY PDOC AT MY APPOINTMENT THAT I FORGET EVERYTHING! I called before the weekend but now I have to wait to hear back and my appointment isn't for a few weeks. Anyone else out there struggling like this? How are you coping? I should also include that I am unbelievably depressed so this just brings me down lower. I'm actually getting a little scared that I may have to go IP for the first time in over a year.
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