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Found 18 results

  1. For those taking Rexulti, I'm curious: Do you take your dose in the morning or at night?
  2. Hi folks, "merry holidays" (lol). So here's my current state of play. There are a lot of variables in play which is something I strive to avoid but then life (and things like not getting divorced or fired) get in the way: I'm tapering off of Wellbutrin XL. It's 6 days since my last 75mg XL dose (before you cry "it doesn't come in 75mg doses!" I was taking 300mg WB XL / 4. Not ideal, but such is life). I'm tapering off of Mirapex. I've been on 0.125mg since the 14th (10 days). I started L-Methylfolate at 10mg (perhaps foolishly - that's a high dose) on the 16th (8 days ago) on the basis that I might have MTHFR mutations. I am shortly getting MTHFR tests done. I started Rexulti 0.5mg 19th (5 days ago). This was reduced to 0.25mg on the 22nd (2 days ago. See below as to why). In summary, a whole shitload of changes all happening in parallel which is exactly what I try to avoid but as I said, shit happens. So here's the real deal. For the last month at least I've been experiencing incapacitating anxiety. The kind that has you in the foetal position in bed, waves of anxiety radiating out from your gut/stomach to each limb. Physical weakness, shaking, incoherence, the works. Naughtily I'd previously ordered Valium online an less-naughtily I've got 0.5mg Ativan off of my PDoc. Neither touches the anxiety. This a.m. I tried 25mg Valium and 1mg Ativan and collectively they helped maybe 10%. I was still completely dysfunctional. The only thing I've found so far that helps substantially is 2+ large whiskies. Within 20 mins of taking them, I feel human, capable, anxiety-free and "alive". Not high or anything - just "human". Without context, that sounds terrible and the easy reply is "you are an alcoholic, go get treatment". But that's BS. Why? because: 15 years ago I went 18 months dry and it didn't help at all. I was more depressed overall from missing out on all the social engagements. (I was like 25). In Feb I went inpatient where they declared my alcohol intake "the problem", made me abstain for 3+ months and guess what? it didn't help my depression at all I don't wake up crazying alcohol I don't want to drink alcohol I've taken many, many other med regimens where this incredible anxiety is not present e.g. SSRI's , TCA's, MAOI's. It seems something particular to either (or both Wellbutrin and Mirapex). As of tonight I'm dropping the Mirapex, even though it's a tiny dose and my PDoc wanted me to remain upon it. Tough shit. As of today I dropped my L-methylfolate intake from 10mg to 2.5mg since I've read that a long-term starvation of L-methylfolate (such as my postulated situation), followed by a "downpour" of l-methylfolate can make you feel even worse. So I'm toning that down. Finally, my questions: why is it that only the alcohol is relieving this incapacitating, incredible 10/10 strength anxiety? (and I have 20+ years of anxiety to know when anxiety is worth a 10/10 rating) am I exhibiting alcoholic tendencies? i.e. am I an alcoholic are my proposed actions (dropping L-methylfolate dose, stopping Mirapex, reducing Rexulti dose) along the right tracks? any other advice? Curled up in bed throughout Christmas, in bed, with 2 young kids is killing me. Concurrently so is the prospect of requiring alcoholic rehab. Some subjective insight would be a golden Christmas present from you to me. Thank you, Pete
  3. Hello everyone, I hope everyone's December has been off to a good start. I am back, on the med merry-go-round and also sober from opiates.... Again (16 days as of now). So I was taking wellbutrin as an add on to my Prozac, and it really didn't help and might have made me worse, losing dramatic amounts of weight, a lot of intrusive thoughts, very depressed (though that's probably just it not doing much for it. And getting off drugs.) so I'm now on the Rexulti starter pack. I'm here seeking others experiences with abilify and rexulti, since they are both dopamine partial agonists and 5-ht1a partial agonists, amongst other things. I'm very nervous about taking an antipsychotic for depression, though... And just want to know of other's experiences starting these medications. How were the side effects? If you had any, did they eventually go away? Did you gain weight? I appreciate anyone who shares their experience. I've asked about these meds before, but I'm so nervous about it I just want reassurance. A lot is changing around me. Thank you all so much, and I hope the holidays have been treating you well.
  4. I will try to keep this brief. I was always depressed and my senior year of college (a year ago) I had a major psychotic break where I literally thought I was flying through the universe. I was hospitalized in for two weeks, and I have been trying to fine tune my meds. I am working closely with my Pdoc, but am getting very discouraged. Any input would be appreciated. Lithium is what brought be out of my mania, and I have been on 900mg er every since. I have gone thru Latuda. Could only get to 60 mg. I took with food, but still felt ill most of the time. Cannot take Lamictal due to headaches. Tried Vryalar and I felt like I was crawling out of my skin. I am now up to 4mg of Rexulti as of last weekend. My Paranoia is the highest it has been since my hospitalization. Saw my Pdoc Friday and he said too soon to tell on the increased dosage and I can go from 7. out of 10 to 3 out of 10 in a matter of minutes. He added a small dose of Lexapro to help with my depression. Rexulti has been the best drug from a side effect profile. If I could rid myself of the paranoia I would almost be normal. Does anyone have any suggestions? Really appreciate it.
  5. Hi there, I was just wondering if anyone here has tried Rexulti as an AD adjunct for depression. Please tell me what you thought of it, I know it's very similar to Abilify, but surprisingly Rexulti under my insurance + the manufacturer discount card is cheaper than generic Abilify, so I want to get familiar with it. I have only had one true experience with an AAP, Seroquel, and it was actually really nice but it made me sleep like a rock, so I got off it years ago. I'm not switching to Rexulti at the moment, but my psych let me know it's the next option if Wellbutrin doesn't work out. Again, let me know your experiences with it, and I guess Abilify too since they are similar. The thought of being on an AAP scares me, with all the side effects and such, especially for depression. But I have read Rexulti and Abilify both have "pro-cognitive" effects which is exactly what I need. Also, has it helped with your anxiety at all? Do AAPs generally help with anxiety? Because if I'd be able to get off Klonopin that would be a plus. Thank you all for any replies!
  6. Just wondering if anyone out there has had any experiences with the medication Rexulti (brexpiprazole)? My psychiatrist chose to give this a try (2mg) after evaluating and attempting to treat my persistent manic symptoms -- I would go days without sleeping and not feel tired, racing ideas and thoughts, increased in "goal-directed" activity like cleaning the kitchen for hours and sexual promiscuity, inflated self-esteem, inattention or inability to focus, pressured speech, rapid talking, and hyperactivity. Seroquel is super effective for stopping my mania but the negative cognitive effect and zombification I experienced were too much, and this was only at 50-100mg If you have tried Rexulti please share your experiences with it in terms of treating your symptoms of bipolar disorder, whether or not it worked for you, side effects you experiences, and the main symptoms that resulted in you trying this medication. So far it has been about a week on Rexulti 2mg, and I am beginning to notice a slight increased in motivation and better time-management, which really surprised me given my past experiences with AAPs. This could be due to other medication, as my dexedrine dose has increased from 40mg to 60mg, but I have been on this high of a dose in the past and not noticed the increased thought organization and motivation to complete tasks/assignments before the last minute. It hasn't directly induced sleep as Seroquel did, but I do notice I am getting on a better schedule. Also, if you have not tried Rexulti but have been on Abilify (aripiprazole), I would be happy to hear your experiences as well, given that the two are similar in structure and chemical composition (I acknowledge that despite this, the two can still have very different and distinct effects).
  7. Mods, please feel free to move this if it's not the right place or if another place would give it better visibility. Hello! I've been away for quite some time, but here's a quick summary of my crazy: I have major depressive disorder, dysthymia, and generalized anxiety disorder. I've been in remission for about 10 years but had a relapse recently after two very sad overseas funerals, a visit to my parents (Dad has Alzheimer's, parents underwater on their mortgage, Mom probably has some undiagnosed mental health issue but refuses to seek treatment), and yet another close friend having a baby (husband doesn't want one, I do, we're working through it but it's pretty upsetting for me). This ain't my first rodeo, so I did all the things we're supposed to do. Went to my pdoc (had to get a new one because the old one didn't take HIPPA seriously enough for me), got a new tdoc, joined a new gym that's at the local hospital and includes nurse evals and sessions with a personal trainer every 6 weeks, found a dietitian, started doing more meditation, etc. Meds going into this: 150 mg Wellbutrin XL, 5 mg Lexapro, 18 mg Concerta PRN, .5 mg Ativan PRN, Seasonale (awesome birth control pill where I get 4 periods a year) Pdoc had me stop the Concerta, increase Wellbutrin to 300 mg, and add Rexulti. I'm supposed to do 2 weeks at .5 mg (done one so far) and increase to 1 mg after that, come back in a month. First 3 days of Rexulti I was incredibly sleepy. I hoped that that would be a temporary side effect, and it was. At this point, 1 week into the .5 mg of Rexulti, I am neither anxious nor depressed, but I weigh more than I ever have in my life and my clothes no longer fit. Guys, I can't afford a new wardrobe. I started this journey with a goal of losing 15-20 lbs. Now, with the same goal weight, I have to lose 25-30 lbs. I'm not overeating. I'm doing everything the dietitian suggested. I'm doing 40 min. of cardio 3-7 days a week. The depression kept me away from the gym for a while, but I'm getting back into it. I'm going to try to get in to see the pdoc again next week, even though I'm supposed to wait until next month. I'm really hoping that the weight gain will be temporary, but I have a sinking suspicion that it won't be. I don't really want to stop the Rexulti because I feel better than I have in a long time, even before the most recent depressive episode, but I also really want to be at a healthy weight and be able to wear my clothes. So, what do I ask? Would increasing the Wellbutrin balance the weight gain effects of the Rexulti? Would a weight loss medication help? I had another pdoc suggest something like that when I was gaining weight on Prozac, but I ended up switching to another SSRI instead. Thanks in advance! Here's a picture of my puppy having an existential crisis:
  8. Does anyone else have experience with Rexulti completely destroying their depression? For me, Rexulti almost had a same day anti-depressant effect and controls depressive episodes acutely and astoundingly fast. I literally feel anti-depressant effects in as little as 3 hours after I take it. When I look back to when I was on it, I now realize that I didn't have a single bout of depression during that time, it just was not super effective in controlling mania. I think Rexulti is a hell of an anti-depressant, a way improved drug than abilify with less than half the side effects, no lethargy or cognitive impairment either which is always surprising to find in an antipsychotic. I know it has an indication for adjunctive therapy in adults with MDD but none for bipolar depression... maybe Lundbeck is just waiting for close to the expiration of the patent before the release new clinical trial data and extend their patent after they get the bipolar depression indication approved, but that's just a thought. Anyone else have a similar experience with Rexulti, brexpiprazole? Please let me know about your time on the medication and if it sat well with you or not so much. Interested in if others are also getting this rapid and significant anti-depressant effect from this drug or if it's just me
  9. Hello everyone. Did a search on the forums and found that there weren't any recent threads compiling everyone's experiences of Rexulti. I've recently started taking Depakote. I hit a mixed state and we went up to 25mg on loxapine to compensate but it caused too much akathisia and we needed something to stabilize me quickly without using the higher dose of loxapine. Depakote did a better job of that than the oxcarbazepine that I was taking originally. Now that I've titrated up to 1000mg, I feel like it does a mostly good job at getting me to a better baseline. Just went to 1500mg for 3 days and had to go back down to 1000mg because I started to become depressed. Now that I've reduced it back down, those depressed feelings have gone away. I have more pep back in my step and I'm more engaged in my work. No issue really. The only problem is that I sometimes have breakthrough anxiety that I manage with 0.5mg of alprazolam or 5mg of loxapine depending on if it leans more towards anxiety/panic or leans more towards intrusive thoughts (respectively). I would like to rely on PRNs less, and I've been thinking about swapping out my nightly 10mg of loxapine for a daily dose of Rexulti. Could still use the 5mg loxapine PRN along with the alprazolam but I wanted to aggregate people's experiences in one thread to get all the data before I make a decision. My next pdoc appt is 11/17. Ok, go!
  10. Hey guys, long time lurker here, and I'd really like your input on something. I'm a bit stuck when it comes to treatment, and I'd like to hear some peoples' opinions, as I wont be able to see my doctor to talk about it for a little while. I’m currently diagnosed as having GAD and MDD, but I’m starting to think I have a bipolar spectrum disorder. Here are some points: Failed multiple antidepressants (Zoloft, Lexapro, Prozac, Viibryd, Pristiq). Failed and/or had too many side effects Had side effects on every serotogenic antidepressant, even while augmenting (Wellbutrin, Buspar) like sexual dysfunction and extreme fatigue Atypical depression — BP Depression has excessive sleeping with a lot of daytime fatigue and an increased appetite, opposite of MDD Very anxious — BP much more likely to be accompanied by stronger anxiety symptoms The fact that “If all the treatments don’t work, maybe you’re treating the wrong thing” Excessive nighttime eating (seen in BP Depression vs unipolar) Racing thoughts Earliness of first depressive episode (age 19 at the LATEST), and research shows it’s very likely to be bipolar disorder if before the age of 18/20/25 (experts disagree on the age) My anxiety symptoms could actually equate to mixed state Losing and regaining interest in hobbies (I’ll enjoy my “typical” hobbies one day and then later, zero interest / motivation) Cousin has BPII (I know immediate relatives are the key, but still, a data point) Online shopping addiction (computer, iPad, something new in the mail every day) The fact that Bipolar Spectrum Disorder doesn’t require mania/hypomania, just multiple non-manic markers of bipolar (see links below for source) The odds that I have treatment-resistant depression coupled with very prominent anxiety, and considering my episodes of depression aren’t THAT bad that they would be so hard to treat So, what do you guys think? For me, it would be a big relief to get a diagnosis as somewhere on the bipolar spectrum, as I've tried so many meds already, and I just wanna feel better If anyone is curious as to my regiment and past meds, I'd be happy to post that as well. Thank you all so much for taking the time to read and respond! It means a lot! some sources: http://psycheducation.org/diagnosis/ https://www.healthyplace.com/bipolar-disorder/bipolar-depression/differences-between-unipolar-depression-bipolar-depression/
  11. How can those of you who have been on Rexulti or Abilify the experience of akathisia? I think I am experiencing it as I cannot sit down not even for a minute without getting up and going to the other side of the room to get a cup and then walk around my house, as it almost feels uncomfortable to sit still unless I take my as prescribed xanax dose and valium together. Ambien helps with the restlessness at night obviously because it works well for my insomnia. If you've been on other atypical anti-psychotics I would love to hear about if you have experienced or are having akathisia and please tell me more about how this symptom makes you feel and how it affects your lives. Because I feel like it is affecting my ability to do anything for a sustained period of time. Should also mention that I didn't have my ADHD medication for the last 2 weeks so might have been a small factor in the equation. Anyhow 1 any experiences with akathisia 2 how did you deal with it or treat it 3 how long did it last for? did it stop when you discontinued the drug? etcetera. 4 how you would best describe it and how it felt for you, what it made you feel like you had to do or that you did or do? 5 what medication and what dosages were you on? Had you recently changed medications or dosages? etcetera Thanks everyone!!! Can't wait to see the post and read other's experiences as well as sharing mine!
  12. I have never participated in a blog before, but found this when I Googled symptoms of Rexulti. The answers were intriguing and the people seemed real, so I decided to try. I'm interested in hearing about what other people are experiencing. I've been taking it for about 10 days and it is definitely working. Changing the time of day when I took it helps with the insomnia. Adding Vyvanse helps with the urge to eat everything in my house. Xanax helps the anxiety. I still get a little dizziness/lack of coordination (bumping into corners/dropping my coffee). I would really love to hear how other people are doing. Thanks.
  13. I just started Rexulti today, I was wondering if anyone has had weight gain with this?
  14. I've been on 2 mg of Rex for 2 1/2 weeks now. It's been amazing. About 3 days ago I noticed a rash on my left shoulder. It is really tiny bumps with white heads on them like tiny pimples. They have a slight itch as well. I thought nothing of it until applied some hydrocortisone to the affected area a couple of times a day for 2 days. Needless to say the rash is still there and has spread to my other shoulder. Could this be caused by the rexulti? I read that one of the side effects is a rash. Has anyone experienced this? Tonight I took a benedryl.
  15. Well, I started my first dose of Rexulti tonight. 0.5 mg. I'm adding it on for depression, which is proving to be rather medication resistant, and I'm a previous Abilify user. I took 2mg Abilify from about October 2015 to May 2016. Stopped it because of severe restlessness and an overall feeling of "not myself", which laughably enough I still feel. I also was emotionally deadened, which I thought was a negative until I've been off it and sobbing all day, begging the sky to die, having mood swings, anger outbursts, you know. I've decided to give antipsychotics another go because maybe emotionally deadened is a good thing! I gained no weight on Abilify, and in fact have gained after quitting. Taking the Rexulti along with my 20mg Trintellix and 150mg Lamictal. What experience does anyone have with this new drug?
  16. Please no judging... So for two years I have had extreme anxiety and depression. To the point where I couldn't leave my room much of the time. My boyfriend was extremely helpful, he is amazing and wonderful, to the point where he doesn't deserve someone like me. This past year I have been trying so hard to love him, I do love him but I'm not really in love with him. I want to be with him so this feeling would get my anxiety and obsessive thoughts going non stop. We just don't have that connection I feel a couple should have. He is very stimulating when it comes to anxiety and it had pushed me away a little. Recently my doctor put me on Rexulti. I started feeling better instantly. The feelings for my bf just fade more when I thought they would get better. For 2 years I thought it was my anxiety and depression pushing me away, maybe not... recently I ended up kissing a guy friend. I freaked out and told my bf I needed some space and a few days to think so I went and stayed at a friends house. I realize I made a mistake but I still don't know if I went back home because I felt bad for my bf who was very sad or if it is because I missed him. He thinks my rexulti is causing all of this and now I'm paranoid that it could be drug induced mania. But the thing is before the rexulti I had lost interest in him. Could it be that I'm feeling better and seeing more clearly, or that my meds are effecting me badly?? Please no harsh comments. Feeling lost . P.s. I am not diagnosed bi polar
  17. I went inpatient back in June and the doctor there added depakote er 1000mg to my regimen along with rexulti 2mg to go with the zoloft 100mg, and topamax 100mg twice a day that I was taking. It was working wonders. I was finally stable. I was also very sleepy. My original pdoc said if depakote er at 1000mg made me too sleepy then to try it at 500mg or one tablet at bedtime. I have been scared to do that because it was working so well! But, I was sleeping all day and all night also. This week, i decided to take my pdoc suggestion and try it at 500mg at bedtime. I am a little more awake but I still need a caffeine jolt in the mornings or I am down. What I have noticed is that I am quickly pushed into mania (I get so much housework done!!!!) And I stay wired until I take my ambien at night to go to sleep. I have done this since probably Tuesday or Wednesday when I started. Now today was different. Today, was more complicated as it was .... more on the depressed side. My husband asked me what was wrong and I said nothing and everything! The slightest thing could go wrong and wreck my entire world and I started bawling. I haven't felt like that since I started taking my new regimen. I am fixing to go back to the way I was taking it before, it's just overwhelming thait feels like I have to choose between stability and the ability to function!
  18. I haven't seen any recent posts on this drug so here goes. Because I'm sick of the weight gain, I'm in The process of switching from Lexapro + abilify to Lexapro + Latuda. My diagnosis is MDD, GAD and panic disorder. I loved Abilify, it was my miracle drug that made me a new person but with only one side effect, constant weight gain. Latuda hasn't been as effective so far but I'm going to try to go up on my dose. i saw my pdoc today and she suggested that I do some research and see what I think about Rexulti (I actually really appreciate that she encourages me to do my own research). She said if Latuda doesn't work, Rexulti is an option. id like to hear about anyone's experiences on Rexulti, specifically whether it caused you to gain (or lose) weight. Other than controlling my depression, weight loss is my main goal right now. It's very hard to find anecdotal experience with this drug, as it's so new. Thanks!
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