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  1. Why do strong SRIs (serotonin reuptake inhibitors) often cause / induce apathy, indifference and laziness? Maybe not in everyone, but it's one of the most common complaints. I regularly read about it on the internet. I myself was affected by it. My questions would be: 1.) What causes it? 2.) Were you affected? 3.) Did you successfully get rid of these specific side effects? If so, how so? 4.) Further comments regarding that "phenomenon"?
  2. Both are second-generation SSRIs, both exhibit minimal drug interactions via Cytochrome P450, both are the most prescribed SSRIs and are considered first line antidepressants. Who's been taking both and what were your experiences? (How did they compare to each other?). I am looking forward to read your experiences... Which one did you like more?
  3. My brief period (6 months) on Sertraline has been that it sapped my creativity and basically made me not want to do anything, not feel anything. I just sit at the computer and watch videos and occasionally walk around, or eat, or go to the bathroom. I just don't have any drive to really do very much of anything, except what is needed for continued survival. I don’t even want to watch movies and series! Is that normal?
  4. In your experience have you taken an antidepressant specifically an SSRI and it made you activated, agitated, irritable and unable to sleep
  5. Did you ever have a bad reaction to SSRIs? How did you treat it? How long did it take to get to normal?
  6. I know that a lot of bipolar folks take an SSRI as part of their daily regimen of meds and apparently it seems to help. But there's some growing concern in the pdoc world now that SSRI's may be causing manic symptoms and even directly causing manic episodes. I was on SSRI's for 10 years before quitting last October. In chronological order: Celexa, Zoloft, Celexa again, Lexapro, Zoloft again, Prozac, Zoloft again briefly, back to Prozac to close it out. For me, personally, after stopping them altogether, I was able to see what they were doing to my system. I truly believe they made m
  7. So I was manic for 8 weeks. I am now severely depressed and my pdoc took me of fluoxetine when i was manic, but now she has put me back on fluoxetine 20 mg. I'm worried I will become manic again. I had a very bad manic episode this time and don't want a reccurance. If you became manic on an antidepressant how long did it take for you to become manic. Was it gradual or sudden? I wonder could I recognize symptoms quickly and go off it.
  8. Hello all, I have OCD/Anxiety/Depression I was on: - lexapro: 4 years Started late 2010. 10 increased up to 60 (there was single day 3 pills cant remember 20mg or 10mg high up dose) short time. decreases down to 5. and stop points with rejected change in meds. luvox: 3.5 years started early 2014. 150 ended in 100 decreased down to 50 after that 1.5 weeks attack of continuous eye pains. And stop points with rejected change in meds. and last full stop. What im feeling after approx. 7 months after stopping: 1.5 weeks atack of continuous eye pains. after the attack, righ
  9. Hi guys, I am suffering from Dystymia and SAD and have been taking Sertraline 50 - 75mg for over a year now. It helps with psychosomatic ailments and moderately attenuates the anxiety & fear. My problem with Sertraline is: It makes me an apathetic zombie, indifferent to life and very unmotivated. I have sleep disturbances, the sleep is unrestful. I've also lost quite a bit of weight and am more agitated. Besides that I have hot-flashes and palpitations on a regular basis. My pdoc said that I will have to live with the sides and that he can't do anything about it. He advised me that I
  10. There is a certain irony here: "Ugh, tricyclics! Low selectivity for the serotonin transporter over the noradrenaline transporter, and what's with all the antagonism at histamine, alpha and 5HT2A receptors? Dirty stuff! Thankfully this is the 90's, and we have Selective Serotonin Reuptake Inhibitors!" "...eh, maybe you do need a bit of a noradrenaline boost on top. Thankfully this is 2000, and we have SNRI's!" "...and maybe it would be nice to have some histamine/5HT2-antagonism-mediated anti-anxiety action, too. It's 2010, try some Seroquel or Mirtazapine on top of your antidep
  11. Hi, I have been diagnosed with Depression and SAD. I've been on Zoloft (75mg) for 3 months now. It's okay for SAD, but it is very "numbing": I've never felt so amotivated, apathetic and indifferent. Zoloft also exacerbates my agitation. Is this normal? Will it become better? Thanks and greetings, Alfed
  12. Hello Comrades, I've been taking Sertraline (50mg daily) for 9 months now. Reason for taking Sertraline: Depression & SAD. Maybe some GAD. So Sertraline treats my baseline anxiety quite well, also got rid of digestion problems, but I am struggling with side effects: Motor restlessness, agitation. I've always been quite "hyperactive", but Sertraline has worsened it by a good amount. I cannot sit still, I feel I have to walk, to pace. I move my fingers and toes to "release" some of the energy. Also lots of fidgeting, rocking back and forth. I have the urge to crawl out of m
  13. I have bad akathisia right now, driving me to suicide thoughts. If you don't know akathisia it is an intense restlessness both physical and mental. Every cell is screaming do something! DO SOMETHING! You twitch, pace, smoke cigarette after cigarette. You do not sleep. Your thoughts run wild. You see the only solution as ending your life. I'm typing this as an alternative to pacing, crying, banging head against wall. It is a fairly common side effect to neuroleptics and a less common side effect to other psychiatric drugs. I got it from 9 days of 20mg fluoxetine, then they switched to
  14. Hello there, I'am taking Duloxetine 120mg for Depression and Pure O (OCD) since Feb. 2017. Unfortunately, I still have intrusive thoughts and some symptoms of depression (low mood, no energy etc.), although I can handle my everyday life somehow. However, the whole situation is not satisfying for me and my family. I'm constantly tired, lethargic, grumpy, hungry and unhappy. So what's next? I've already tried to augment with Seroquel (300mg; horrible, horrible experience) and Abilify (2,5mg-5mg, quit working after two months). What's about switching the baseline med? Can I go back to S
  15. I am a 28 year old female who recently was perscribed Wellbutrin 150mg per day. I had heard all of the stories about people's sex drive going through the roof, and so I was excited to start taking it. However, on day two, I noticed that I was having a difficult time achieving an orgasm, so I IMMEDIATELY stopped taking it. It's been two weeks, and I still don't feel back to normal and I am officially starting to panic! I'm a pretty high strung person if you can't tell, and I'm wondering if I'll ever be normal again. I can still get really turned on, but my orgasms aren't as strong and today I c
  16. Hi! I'm new and hoping to get some input opinions on things that can help me. I've been diagnosed with depression for almost 6 years now, just after I delivered my daughter in Feb 2012. I was on and off sertraline for about 3 years until I started having some serious anxiety attacks and then hydroxyzine was added. But all hydroxyzine does is knock me out. Sertraline never did much for me so in January 2016 they put me on Prozac which helped significantly with the anxiety but also made me not care if I lived or died. I was numb to everyone and everything around me including my husband and 2
  17. I wonder whether there´s an SSRI antidepressant also effective for sedation. From my short little search, it seems sedating ADs (Mirtazapine, Doxepine, Trazadone etc.) rather belong to other classes instead of SSRI.
  18. The med tinkering is driving me nuts. Anyone with me here? Sigh. I have had depression and major depressive episodes for the past 20 years, but I have only been doing the med thing for the past three years. I feel like I get so close to finding a combo that works, albeit with some intolerable side effect... and then I try to get the combo better and wind up making it worse. My latest foray brought back my PMDD crying/depression/irritability for the past week and I'm just at a loss of what to do next. My psychiatric nurse is pretty much up for whatever I want to try, but I don't know what to do
  19. Hello, everybody. I just wanted to post this thread out of curiosity for those of you who have taken Zoloft or Sertraline HCl before. I've been on it for about 5 years now, started at 100mg after titrating up to it for a month or two, and stuck to that for 2 years. After 2 years, I had an episode of anorexia that landed me IP where I was diagnosed with obsessive compulsive personality disorder, and was titrated to 250mg daily at the end of my stay. After leaving, I kept it at 250 with my pdoc, but we decided to go down on it since neither of us thought the dose was having a clinically sign
  20. Howdy i'm new here, Question. I'm on 10MG lexapro on week 7 (prescribed for anxiety!) and I never have really felt anything much either way from this stuff- (a good thing?) my anxiety continues (but perhaps not as bad?) and in some cases I wonder if if it's Lexapro causing anxiety...I feel like 7 weeks in I should be seeing results and as such I wonder if this is a wrong drug for me...I've taken it in the past and I don't really seeing it doing much either way.. The anxiety feeling is vaguely different- it's not a mind thing but a body high sort of thing- my mind is solid and not choosi
  21. Hi All Jusy looking for some support and advice. I have moderate - severe OCD the intrusive thoughts type or "pure O" as they call it. Psych has started me on Prozac. Oh. My. Goodness. My anxiety has gone through the roof, I am jittery and the intrusive thoughts are coming hard and fast. Some new ones, like really bizarre things. For example, I was making chicken last night and got freaked out at the thought of cutting up my baby and eating him!!! Really intense and think I'm going crazy!!! Today I'm on day 6 and I feel shit. The mornings are the worst, I have to run to b
  22. Hi guys, I'm reading parts of a book (linked below) that notes how SSRIs are sometimes known for impeding the absorption of other meds that are being taken concurrently. It notes that Luvox is the worse SSRI regarding this. The book says that Klonopin and Xanax are two of the drugs that interact with Luvox through "CYP 3A4 inhibition." Does this mean that Klonopin and Xanax are less likely to work when taken with Luvox? By extension, would this mean that any other meds taken together with the Luvox will probably not be absorbed as well by the body? Page 536, along with Table 32.29-2:
  23. Hello all, I am new to this website after doing lots of research on Latuda over the past 3 weeks. For years I had been suffering with anxiety/depression and nothing seemed to work for me. My tendency became to self-medicate with alcohol and that obviously just made things worse. This all started in my early to mid twenties as I slowly became a shell of my normal vibrant and social self. Just a year ago I was diagnosed with Bipolar 2 and the direction of medications prescribed to me took quite a turn. Originally my prescriber had started me on Lamictal to "create a base" for the antidepres
  24. Hello fellow humans! I'm xlmplmplmp, which is just an unpronouncable internet moniker. The powers that b got me when I was young (12 years old) and told me I had OCD and needed SSRIs. Fast forward thirteen years and I decide I'm done with meds and taper off too quickly. Low and behold I discover the wonders of PSSD and furthermore experience the consequences that 10+ years of SSRI usage have on the developing brain. I discover and devour Robert Whitaker's Anatomy of an Epidemic and realize we've all been fucked from the beginning, by design, for the benefit of the most ruthless organizatio
  25. Hello! Erectile, libido, and orgasm disorders are very common when taking SSRI or SSNI drugs. This reduces quality of life, and can cause secondary depression. I wish to find a way to manage my psychological ailments, while retaining normal sexual function. Background: I have anxiety disorder and mild depression. My first SSRI/SSNI was Cymbalta. It worked very well. However, after a few years, I realized I had erectile dysfunction. I am no longer on Cymbalta. Why is there hope? There is anecdotal evidence from various sources, which state at least limited success with various dr
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