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Found 9 results

  1. It would seem so, at least according to many studies... Gillman regularly mentions that his patients did substantially better on TCAs than on SSRIs (Sertraline might be an exception). Especially Amitriptyline, Clomipramine and Imipramine seem to be superior in effectivity. Is it wise to completely shun those very effective older antidepressants?
  2. I've been reading the following articles: https://psychotropical.info/clomipramine-potent-snri-anti-depressant/ https://psychotropical.info/tca-intro/ https://psychotropical.info/snri-intro/ Seems to be a pretty potent drug: SNRI, antagonist of the alpha1-adrenergic receptor, the histamine H1 receptor, the serotonin 5-HT2A, 5-HT2C receptors, the dopamine D1, D2, and D3 receptors, and the muscarinic acetylcholine receptors. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system; so that speaks for itself.
  3. hello, has anyone here been on this old drug for social anxiety or any type of fear related disorder? I heard it works great for anxiety and I will be starting this medication soon. Im wondering if anyone felt like more Calm in stressful situations after starting this drug? Like more confident etc.
  4. There is a certain irony here: "Ugh, tricyclics! Low selectivity for the serotonin transporter over the noradrenaline transporter, and what's with all the antagonism at histamine, alpha and 5HT2A receptors? Dirty stuff! Thankfully this is the 90's, and we have Selective Serotonin Reuptake Inhibitors!" "...eh, maybe you do need a bit of a noradrenaline boost on top. Thankfully this is 2000, and we have SNRI's!" "...and maybe it would be nice to have some histamine/5HT2-antagonism-mediated anti-anxiety action, too. It's 2010, try some Seroquel or Mirtazapine on top of your antidep
  5. It's the time of year again when I start having trouble sleeping, and I've tried numerous meds for insomnia (and at the same time I have hypersomnia too... go figure...). My insurance doesn't cover Silenor, brand-named doxepin in 3 mg and 6 mg micro-doses, so my pdoc gave me Sinequan (doxepin) 50 mg. I've tried doxepin before, but at 75 mg, which for some stupid reason my insurance treats as tier IV non-preferred brand name, but all the other doses my insurance is like "oh you're cool, that's tier II..." Anyway... So the doxepin 50 mg worked extremely well the first night, and the first n
  6. Hello Comrades, I've been taking Sertraline (50mg daily) for 9 months now. Reason for taking Sertraline: Depression & SAD. Maybe some GAD. So Sertraline treats my baseline anxiety quite well, also got rid of digestion problems, but I am struggling with side effects: Motor restlessness, agitation. I've always been quite "hyperactive", but Sertraline has worsened it by a good amount. I cannot sit still, I feel I have to walk, to pace. I move my fingers and toes to "release" some of the energy. Also lots of fidgeting, rocking back and forth. I have the urge to crawl out of m
  7. Researching TCA's because it may be something I will bring up to pdoc. I have only tried 1 (Nortryptaline). Does anyone know how to choose a TCA by the "binding profiles?" Like for example if someone wants something less sedating with little potential for weight gain, which TCA would be better?
  8. Just a poll to see what your take is on MAOI's or TCAs (for Depression)...which do you prefer, and WHY? Both are not the 1st line of treatment (says my pdoc) she is hesitant to suggest either, but i have not tried either class. Is one or the other more helpful and are they worth the side effects? (I've heard both have pain-in-the-butt side effects but why not try)
  9. I'm just wondering if anyone has any experience with Doxepin for sleep as well as depression/anxiety? I'm currently taking 150-200 mg of Seroquel XR at night, but want to switch to something else with less effect on appetite and possibly with less day-time sedation, too. Less expensive would also be a bonus. I know Doxepin hits histamine receptors first and foremost, and then begins to interact with various norepinephrine, serotonin, and muscarinic receptors. I'm just curious if anyone has noticed an effect on depression or anxiety in addition to sleep benefits; I want something that will b
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