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Hi all, I'm a 20+ year sufferer of extremely TRD and am trying LSD (1P-LSD, more specifically) microdosing to help lift my mood and combat anhedonia. I'd love to know if anyone else has tried this. Specifically: what was your regimen? e.g. every 3 days?, dosage, substance, method did any initial beneficial effects increase over time? if so, over what kind of period? did you develop a tolerance? did it help with your anhedonia? did you try more than a microdose e.g. 1/4, 1/2 or even a whole tab? If so, how was that therapeutically? FTR, I'm taking 10ug (1/10th of a tab) every 3 days using the volumetric method. I felt notably more energetic and less severely depressed within an hour of dosing. This persisted for ~ 14 hours. I couldn't sleep. Now, the next day, I feel kind of back to normal (i.e. feel very depressed and anhedonic), which is very demoralising. Thanks, Pete

This may be more useful for people like me who have pretty much tried it all and are therefore stuck waiting for new research or for something new to come on the market. On my 24th medication and still struggling, I am most definitely treatment resistant. My pdoc specializes in TRD and keeps current on the research. He works/networks with researchers in various places do he almost always has some cutting edge new treatment to suggest and he didn’t disappoint this time. He told me about a new study that looked at metabolites not just in the blood but also the brain via spinal tap. The study (which only looked at subjects with TRD) found that 70% had a shared metabolic deficiency; they all had cerebral folate deficiency. It should be noted that their serum levels were normal, so a regular blood test would NOT pick up on CFD. Treatment involved folinic (NOT folic) acid; unfortunately, it can take 3-4 months to build up enough folate in the brain... but the trade off is that basically ALL subjects who had the deficiency and underwent treatment for better. It’s a small study of course, but my pdoc thought it was very promising, so he recommended I get the spinal tap to test for the deficiency. The test is sometimes covered by insurance, he thought out of pocket it would be about $1,000. And it does require a spinal tap/lumbar puncture, if that matters. For my part, if I could fix myself for $1000 and a needle in the back, sign me up! Anyway, I’ve always appreciated how my pdoc does so much research into novel treatments, I like to pass on his ideas, particularly for those with doctors willing to try different things. https://www.ncbi.nlm.nih.gov/m/pubmed/27523499/

https://medicalxpress.com/news/2018-07-lack-molecule-severe-treatment-resistant-depression.html

Hello, I am new here and hoping to find help if not a cure for my disability. I call it a disability because I find it extremely difficult to deal with everyday life. Unable to focus on the simplest of tasks or even interact socially with people anymore. I've tried therapy for many years but have come to the conclusion that the therapists are just there to collect my money week after week. I've also gone the medication route which I discontinued a year ago due to financial difficulties. I've been told I have depression, Bi-polar Disorder, OCD and most recently Treatment Resistant Depression. I'm sure there is more wrong with me, I'm just so forgetful I can't remember it all right now. If there is anyone here that can offer some type of direction or assistance I would be greatly appreciative.