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Hello CrazyBoards, I started 5mg Trintellix a week ago and in a nutshell, felt 40-50% better the very next day. Before I get deafened with shouts of "PLACEBO!", think again since I'm treatment-resistant (20+ years) and never expect meds to work - because they nearly always don't. FTR I've tried tens of med combos, treatments, ECT, dTMS unsuccessfully. They either make me worse, have no effect or help somewhat and then poop-out within 2-4 weeks. Furthermore my mood started dipping significantly 3 days ago so I upped the dose to 7.5mg last night, again not expecting anything and lo and behold, I felt significantly better - like "naturally" or "simply" better today. Has anyone heard of, or experienced such a rapid improvement? Pete
tangela posted a topic in Antidepressants - If You're Crappy and You Know ItJust thought I would share some experience with Trintellix. I started 2-3 months ago on 5mg. mainly for anxiety and depression. I also take a variety of meds to help me sleep. Trintellix can be really nauseating when you start (for at least two weeks) When I moved up from 5mg to 10mg - I became comatose. So, I went back to 5 and it's been great- It' gives a little boost of energy- similar to vyvanse. It helps me not to go home and cry everyday. :-) I seem to eat less- in terms of general snacking. What I have found with this med - is even at this low dose- you metabolize alcohol more quickly. 2 drinks can = drunk. And, if I have a drink and get a little stoned- I'm up vomiting all night. Just putting the warning out there- not drinking is the way to go on this med.... wondering if anyone has had similar experiences...