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Back in September, I had smoked marijuana and not long after had a reaction. Whole body became tense, then my head would snap to the side. I could talk but had to force words out. Then my right arm fused to my side and hands would curl in violently, painfully. Towards the end there was uncontrollable upward eye movements. I was aware and worried but decently calm during it. I thought it was maybe a buspirone/trileptal/welbutrin reaction re: the marijuana but saw a neurologist just in case. He said he's never heard of a marijuana interaction with my meds like that or even marijuana having that reaction in general. Told me it sounded like dystonia and to take benadryl the next time it happens. Fast forward to 6/24 (last week). I went in for knee surgery. When I woke up I was still in a bit of pain so the nurse gave me dilaudid. Now, my perception of time during this is off, but not too long after I started having the same kind of jerking sensations as described above. This time it was less violent. My back kept arching and my neck was snapping to the side. Arms twitching. I was calm about it but the staff seemed confused. They gave me ativan and after a little bit, while i was still spasming, I managed to tell them what the neurologist said and they gave me benadryl. I don't know how long it took to stop, but it did. After, in recovery 2, the anesthesiologist came up to me to see how I was doing. Asked me about buspirone and what I was taking it for. It seemed like he wanted me not to take it but didn't say it out right? I guess my question is, if anyone has had any sort of reactions like this before? I'm not entirely sure what to do with this.

Welbutrin (Bupropion) is a dopamine-norepinephrine reuptake inhibitor; its occupancy at dopamine transporter (DAT) is 23%; whereas over 75% causes euphoria (ex. cocaine). A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron. This results in increased extracellular concentrations of dopamine and increase in dopaminergic neurotransmission. I am currently taking Abilify 400 mg every 3 weeks (~ 20 mg / day) and 300 mg of Welbutrin. I was complaining to my psychiatrist about the side effects of Abilify I was suffering from; depression (low mood), sexual dysfunction, anhedonia, from a condition called "Neuroleptic Induced Deficit Syndrome" . I complained that I had totally lost my motivation, drive, and initiative and was experiencing anhedonia (lack of pleasure), emotional suppression, etc. It is like living in a mental restraint "straigthjacket". So my psychiatrist added Welbutrin. Abilify dampens down dopaminergic activity in three of the four dopaminergic pathways; It is the only Antipsychotic that I know of that can increase mesocortical dopaminergic activity. Other partial agonists like Brexiprazole and Cariprazine might do this also, whereas a silent antagonist cannot. Welbutrin has treated my low mood; I am euthymic now, but I am still anhedonic from Abilify being so frequent for such a dose; I am taking the daily equivalent of 20 mg: 400 mg per 3 weeks. At lower doses Abilify has a more stimulating effect. The Welbutrin he added certainly helps; but is unfortunately not enough. I am considering adding a dopamine full agonist such as Ropinirole, Rotigotine, Cabergoline and Pramipexole to my prescription meds. Some dopamine agonists are useful at treating depression resistant to SSRI-treatment. Dopamine agonists can be given to counteract the side effects of antipsychotics and serotonergic antidepressants. No doubt that dopamine antagonism has a negative effect on mood. In the mesolimbic pathway *(reward pathway)* Aripriprazole reduces dopaminergic activity; which reduces motivation - salience (liking, rewarding), which can be identified as a major source of anhedonia. Aripriprazole does not reduce dopamine transmission in the mesocortical pathway in people whose mesocortical pathway has .less than normal activity. The dopamine boost that Welbutrin provides keeps me stable; counterbalances some of the negative effects of Abilify. I just need more help in alleviating this zombified state of existence in which I am alienated from my own real self. and cannot enjoy the things I used to enjoy; food, drugs, sex. I live in anhedonia, a state of a loss of pleasure; due to the neurological inhibition caused by Abilify. Welbutrin works as a wakefullness promoting agent, a mild stimulant.

I was just prescribed Welbutrin for depression and ADHD. I am only 17 years old and am already showing signs of having an addictive personality. I had illegally been buying adderal pills off friends at school to help motivate me to do homework and get good grades. It worked. I had been making AMAZING grades, and not only that, but I felt like a happy person due to its euphoric side effect of amphetimine as well. At first, I would only take 10 mg every once in awhile like if I had a test or just a lot homework I needed to get done. Then it turned into taking 10mg everyday, slowly turning into taking 20mg, and sometimes I would take 20mg twice or three times in one day. I couldn't handle coming down off it, so I would just take more. Once I realized how out of control I had became, I told my parents. They weren't nearly as mad as j thought they would be. They just wanted to get me help. We went to the nurse practitioner I had been seeing for anxiety for the past few years. I was taking 100mg of Zoloft. I never have any energy of motivation to do anything and that's why I feel in love with the adderal. It gave me the confidence I needed socially and the extra boost of energy. My nurse practitioner prescribed me welbutrin. I've only taken it for 2 days now, but both today and yesterday it made me feel stoned and drunk. I don't even feel human and I just miss having the adderal high, this med is only making me tired and hungry, it's not motivating me to do anything. It's a Friday night and all I've been doing is laying in bed reading about Welbutrin and what it does to people. My throat feels swollen, I'm more emotional than I've ever been (I cry about everything), I'm tired, I feel disconnected from my body (almost like I just smoked a bowl of weed to myself), I wanna eat everything, my mouth is dry, and my anxiety has never been this bad. My doctor went ahead and took me off Zoloft, too. I really want this med to work for me. I don't want to take adderal illegally anymore, I don't wanna be addicted to it, but my depression is the worst it's ever been. My ears won't stop ringing either? Has anyone else felt this way? I hope these side effects will subside and I'll start to feel like a happy, normal person again. Thanks maddie

I was just prescribed Welbutrin for depression and ADHD. I am only 17 years old and am already showing signs of having an addictive personality. I had illegally been buying adderal pills off friends at school to help motivate me to do homework and get good grades. It worked. I had been making AMAZING grades, and not only that, but I felt like a happy person due to its euphoric side effect of amphetimine as well. At first, I would only take 10 mg every once in awhile like if I had a test or just a lot homework I needed to get done. Then it turned into taking 10mg everyday, slowly turning into taking 20mg, and sometimes I would take 20mg twice or three times in one day. I couldn't handle coming down off it, so I would just take more. Once I realized how out of control I had became, I told my parents. They weren't nearly as mad as j thought they would be. They just wanted to get me help. We went to the nurse practitioner I had been seeing for anxiety for the past few years. I was taking 100mg of Zoloft. I never have any energy of motivation to do anything and that's why I feel in love with the adderal. It gave me the confidence I needed socially and the extra boost of energy. My nurse practitioner prescribed me welbutrin. I've only taken it for 2 days now, but both today and yesterday it made me feel stoned and drunk. I don't even feel human and I just miss having the adderal high, this med is only making me tired and hungry, it's not motivating me to do anything. It's a Friday night and all I've been doing is laying in bed reading about Welbutrin and what it does to people. My throat feels swollen, I'm more emotional than I've ever been (I cry about everything), I'm tired, I feel disconnected from my body (almost like I just smoked a bowl of weed to myself), I wanna eat everything, my mouth is dry, and my anxiety has never been this bad. My doctor went ahead and took me off Zoloft, too. I really want this med to work for me. I don't want to take adderal illegally anymore, I don't wanna be addicted to it, but my depression is the worst it's ever been. My ears won't stop ringing either? Has anyone else felt this way? I hope these side effects will subside and I'll start to feel like a happy, normal person again. Thanks maddie

Under advisement by my pdoc, I need to get off of my Welbutrin because it's triggering mania. I'm 4 days into halving my dosage and all I want to do is sleep all day. Is there something I can ask my pdoc to do to help with the excessive sleepiness?