Both are quite similar, and that is no surprise, given that Notrtiptyline is Amitriptyline's major metabolite.
When comparing both, we can ascertain the following: Amitriptyline has somewhat more SERT blocking going on, so might be slightly more "serotonergic" than Nortriptyline, although I am not quite sure if clinically relevant. Both are equally strong NRIs and 5HT2 antagonists. Amitriptyline is a stronger ALPHA1 blocker compared to Nortriptyline, so might cause more postural hypotension. Amitrptyline is a stronger antihistamine than Nortriptyline, so might cause more sedation and appetite. Amitriptyline is a stronger anticholinergic than Nortriptyline, so will probably cause more side effects. (Although stronger sedative and anticholinergic properties might be welcome, depending on the condition)
What I am interested in: Who's been on both and how did they compare? (not only theoretically, but practically)
picture source: https://abload.de/img/nortgpk1f.png
hello, has anyone here been on this old drug for social anxiety or any type of fear related disorder? I heard it works great for anxiety and I will be starting this medication soon.
Im wondering if anyone felt like more Calm in stressful situations after starting this drug? Like more confident etc.
There is a certain irony here:
"Ugh, tricyclics! Low selectivity for the serotonin transporter over the noradrenaline transporter, and what's with all the antagonism at histamine, alpha and 5HT2A receptors? Dirty stuff! Thankfully this is the 90's, and we have Selective Serotonin Reuptake Inhibitors!"
"...eh, maybe you do need a bit of a noradrenaline boost on top. Thankfully this is 2000, and we have SNRI's!"
"...and maybe it would be nice to have some histamine/5HT2-antagonism-mediated anti-anxiety action, too. It's 2010, try some Seroquel or Mirtazapine on top of your antidepressant!"
"...and we do want some alpha1-adrenergic receptor antagonism to normalize the HPA axis! And some FIASMA / BDNF would be nice. R&D, get started! It's 2018!"
"...or just have a tricyclic."
I would not be surprised if they try to market anticholinergics as new groundbreaking anxiolytics in a few years from now...
I've been reading the following articles:
Seems to be a pretty potent drug: SNRI, antagonist of the alpha1-adrenergic receptor, the histamine H1 receptor, the serotonin 5-HT2A, 5-HT2C receptors, the dopamine D1, D2, and D3 receptors, and the muscarinic acetylcholine receptors. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system; so that speaks for itself.
The reviews on drugs.com and other sites also are quite positive.
The following ranking is interesting: http://slatestarcodex.com/2015/04/30/prescriptions-paradoxes-and-perversities/
These numbers are based on aggregated patient ratings. Top 4 drugs:
# Nardil 1.25
# Parnate 1.23
# Chlomipramine 1.22
# Emsam/selegeline 1.07
=> Clomipramine roughly on pair with MAOI, followed by Nefazodone (R.I.P) and Imipramine. Imipramine is also a potent SNRI, but lacks the strong 5HT-antagonism compared to Clomipramine. I suppose that's the pharmacological difference which makes Clomipramine superior... ?
Clomipramine exhibits some antagonism of dopamine D1, D2 and D3 receptors... can one expect some clinical & therapeutic benefits from this?
Clomipramine acts as a functional (potent!) inhibitor of acid sphingomyelinase (FIASMA): http://en.wikipedia.org/wiki/FIASMA
Some interesting graphs regarding antidepressant FIASMAs: http://d-nb.info/1011278227/34
Who here has been on Clomipramine and what were your experiences with it?
It's the time of year again when I start having trouble sleeping, and I've tried numerous meds for insomnia (and at the same time I have hypersomnia too... go figure...). My insurance doesn't cover Silenor, brand-named doxepin in 3 mg and 6 mg micro-doses, so my pdoc gave me Sinequan (doxepin) 50 mg. I've tried doxepin before, but at 75 mg, which for some stupid reason my insurance treats as tier IV non-preferred brand name, but all the other doses my insurance is like "oh you're cool, that's tier II..." Anyway...
So the doxepin 50 mg worked extremely well the first night, and the first night only. After that, I have trouble initiating and maintaining sleep, so I get anywhere from 3-4 hours of fragmented sleep according to my Fitbit. Then I'm tired all day, but I can't really nap because of my stimulant, which is nice because it keeps me going and whatnot, but I don't feel like keeping going because I'm exhausted. So I tried taking two doxepin one night for 100 mg and I actually felt a little stimulated and got about 2 hours of sleep.
So I have two questions for those who have taken doxepin:
If 50 mg isn't working for sleep, do I need to go lower in dose? Like 25 mg or even 10 mg? Does doxepin actually become stimulating in higher doses like some of the TCAs? Thanks in advance for any input!