I'm having a hell of a hard time and experiencing rather weird symptoms. Whether they've anything to do with Mirtazapine (Remeron) is something that I strongly feel but can't quite convince any doctor of. I was put on 15 mg of it in spring 2015 for depression and a severe insomnia - I hadn't slept an hour like since 25 nights back then! The benefits showed immediately within a day and surprised myself and my family. I would sleep well and be in a very happy and cheerful mood. Then however, from summer 2016 I developed some strange food intolerances; caffeine, sugar, fruits containing high amounts of fructose, yoghurt, butter and so on. Eating anything of that would cause me jitteriness and insomnia. I steered clear of those foods. From autumn last year though, a lot of those food intolerances have relented and it changed into intolerance towards medicines and supplements that I was on; the thyroid medicine for hypothyroidism, Vitamin D, Calcium, Vitamin E and could never again tolerate any new medicine or supplement. Symptoms resulting from these are, again, jitters, insomnia and a strange kind of feeling of being struck on the head, like I can't hear anything and the thinking becomes very unclear and blurred. Coupled with this is a weird sensation that if a medicine has any potential side-effect (even physical, such as urine retention), I get it at all costs. So I'm steering clear of the culprits here too. However, avoiding the culprits doesn't end my misery, it just helps in avoiding a whole new set of symptoms, because since autumn 2016 I'm under constant brainfog anyway, have heart palpitations immediately after every meal (but worst after breakfast), have concentration and focus issues, lead a life without any hobbies, wishes or desires. Nothing excites me, nothing interests me and nothing catches my attention. Leave tasks pending for months (the most unlike me habbit), have badly lost my sense of humour. My sense of humour was something that I literally used to pride on, and friends from around the world would call me to fresh up if they were having a dull day. My mind feels numb, although it isn´t as if it´s the sedating effect of the Mirtazapine because 90% percent of the nights I don´t sleep well, and on a lot of nights I feel as if I´m asleep with an awake mind! The GP who put me on it considered it to be just the effects of anxiety and depression and recommended the doubling of the dose to 30 mg. When I contested that, given that I´ve my doubts of a lot of these issues being brought upon by Mirtazapine itself, she referred me to a psychiatrist. He too strongly denies of Mirtazapine having any hand to play on it and instead thinks it´ll be best to combine it with another antidepressant for day-time. He put me on Paroxetine, boom, a flood of side-effects! Then changed to Fluoxetine (Prozac) - third day on it and having weird feelings. The heart poundings are one and is in fact making me very depressed and hopeless!
So I'm in the process of tapering off mirtazapine (Remeron) and seem to be having some pretty shitty withdrawal effects. Some are physical (teeth grinding, fatigue), but some are returning/worsening mental health symptoms (shitty mood and emotion regulation, increased depression, anxiety, indecisiveness, and obsession). The goal in tapering off this med is to eliminate it's "hangover effect," so I'm hoping this is just some extended rebound effect/temporary withdrawal symptoms. I can't seem to get out of bed in morning and make it to work on time to save my fucking life in any case, so it would be nice if I could eliminate one factor in that. It's been 2 1/2 weeks since I went down 3.75 measly milligrams, but I don't know if I can take much more of this.
Any experience with this? Suggestions? Oh, and when I called my psychiatrist, a nurse called me back and said withdrawal effects should only be physical...bullshit, right?
my name is Nicholas and I'm a 21 years old guy from Italy.
I suffered from chronic insomnia from the age of 15 and in mid-February 2017 was prescribed before bedtime the antidepressant mirtazapine at 15 mg and the antipsychotic olanzapine at 2,5 mg. I took them for 2 weeks without improvement. Therefore the psychiatrist increased mirtazapine at 30 mg and olanzapine at 10 mg. Now I believe that he thought I had bipolar disorder type 1 but I hadn’t any mental illnes.
I took olanzapine at 10 mg because I think was only a tranquilizer and because I trusted the doctor.
Olanzapine made me sleep for 13 hours but I was no longer myself. After 5 days I tried to split the tablet but it gave me a strange effect. So I continued for others 15 days at 10 mg because I really needed to sleep. Then in April 2017 I tapered olanzapine in 1 week because I could not live anymore like that. I took it for a total of 48 days.
After this I reduced mirtazapine to 15 mg and 1 week later I stop cold turkey. At that time I took the benzodiazepine brotizolam at 0,25 mg for 2 weeks to help me sleep.
The withdrawal symptoms were terrible for 4 months and I have not been the same anymore.
When I was on mirtazapine and olanzapine I had eyelids fasciculation 2 or 3 times per day. When I quitted olanzapine the eyelids fasciculation ceased.
2 weeks after withdrawal from olanzapine and 1 week from mirtazapine I started to have frequently intermittent muscle twitching in the left thigh and occasionaly pulsating muscles in other parts of the body. After less than a couple of months they have decreased in frequency and intensity but didn’t stop completely. During this period I was forced to take the antidepressant sertraline and the benzodiazepine diazepam because for the new psychiatrist I had obsessive compulsive disorder with an obsession for the damage of antipsychotics. I did not have anything like that and could taper and withdraw after 3 months in July 2017.
Now I think maybe that the muscles twitching have diminished because diazepam is also a muscle relaxant.
In August 2017 I started to have continuous fasciculations in the legs when I lie down and less frequently when I sit while I never had them when I move. Few times a day I had pulsating muscles also in the arms and the trunc but never in the face. I never had muscle twitches in multiple parts of the body at the same time.
In September the muscles twitching moved for 1 week in the lower abdominals.
In October 2017 for 2 weeks the muscles twitches suddenly stopped in the legs and continued in the rest of the body about 10 times per day.
When the muscles twitching returned they were milder. Sometimes the fasciculations are so mild that when I looked at my calf I saw them without feel them. In the legs they have become more single rapid muscular contractions than pulsating muscles.
Soon after I started to have continuos pulsating muscle in my upper lip. The muscle twitch was very mild and lasted 2 weeks but after it I have sometimes pulsating muscle also in my face.
Do you think it is a tardive dyskinesia caused by olanzapine despite I haven’t involuntary body movements?
Do you think it could be some other side effect caused by olanzapine or maybe mirtazapine? It’s 8 months that I’ve it.
I have been visited by several psychiatrists and neurologists and everyone said it was just stress.
Even if I do not have the symptoms of tardive dyskinesia I do not know what else it could be: I’m not stressed and I do not suffer from anxiety, I do not take stimulants, I can sleep, I have had blood tests and I haven’t electrolyte imbalances or hypoglycemia, I did electromyography and had normal results.
The thing that worries me most is that there is a very large amount of medical literature that associates tardive dyskinesia with cognitive impairments.
If it were to be tardive dyskinesia do you think that the fact that for almost 2 weeks the muscles twitches had almost disappeared means that I am healing?
Thank you and greetings from Italy.
I have been on Remeron for about three years for anxiety, OCD, and depression. I started at 60mg, but that was pretty stimulating after dosing it all at night. Now, I take 22.5mg before sleep.
Depending on my legs/hips tension levels, I always get restless legs about 45-60 minutes after my dose, and it keeps me from sleeping right away. I've had this since I started the med, and now that I do yoga/stretching, it's even been worse. Some nights it is very severe. Would lowering to 15mg help? Or anything else? I wonder if it's a histamine or noradrenaline thing. Thanks.
I convinced my gdoc this morning to increase my dose of Zoloft from 150 to 200 mg.
I'm already taking 175 mg actually. With each increase the RLS (restless legs, or feet and ankles in my case) gets worse. I'm supplementing with iron and it seems to help a little. Some one suggested magnesium as well, but this person doesn't know I'm on medication, so I don't know if magnesium will actually work for SSRI-induced restless legs.
Other than de RLS I don't experience much from the Zoloft. I think it's working partially because in some situations these thoughts aren't as frequent and I can concentrate better. Especially when I'm around people, have important things to do. When my attention turns outwards, so to say.
From the beginning of February I do have a lot on my mind. There's a situation going on in my life which is giving me stress and anxiety. It's a big thing in my life right now which could end rather sad. I'll have to wait and can't do much about the situation. To relax and let go I've started running again and listen to audio books a (it's almost therapy, I love listening to novels and it's incredibly useful when I can't sleep right away).
The intrusive thoughts are more frequent when I'm going through these kind of stressful events in life. I don't think the Zoloft is able to help with the intrusive thoughts at the moment. Maybe it will kick in when it's all over. I decided to give the 200 mg a try for about a month.
My pdoc advised Anafranil (clomipramine) but I'm not sure because of the effects on histamine, muscarine and cholinergic receptors. I could handle dry mouth and constipation, but gaining weight and dizziness is something I really need to avoid!
I wonder if going back to Luvox will do the trick or if trying Prozac is an option. They are both SSRI's and Luvox and Lexapro worked incredibly good for me. Zoloft just doesn't and I still don't get that. Pulling out the big guns like Anafranil feels a bit extreme?