"Clomipramine, Tryptophan and Lithium in Combination for Resistant Endogenous Depression: Seven Case Studies" - August 1987 | A. S. Hale (a1), A. W. Procter (a2) and P. K. Bridges (a3)By Skeletor
Unquestionably an extreme combination, but it seems to exhibit powerful antidepressant effects. Clomipramine on its own is regarded by many as maybe the most powerful non-MAOI antidepressant, at least in clinical practice and inpatient care, although the side effects can be quite rough, but combined with Tryptophan and Lithium it seems to be further boosted in its effect size and response rate.
Maybe worth trying before hopping on ECT / MAOIs...
One has to be careful because it is a small sample case "study", but nonetheless quite interesting to read. I encourage all those who have a view or experience to share it with us, regarding the aforementioned medications and especially the combination. Greetings!
just started Lithium yesterday. I know it can take several weeks to work, but I already feel it clearing my head a bit.
question tho. Can lithium make anxiety worse in the beginning - like SSRI’s? Because I now find myself very panicky
I am also on lexapro and mirtazapine.
I don’t know if anyone has info on this or not, but here goes. I’ve looked through the internet and couldn’t find anything. Does anyone know if taking lithium can affect. DTC (direct to consumer) DNA testing (Ancestry, etc.)? I’ve read some chemo meds may affect it, and that things such as denture adhesive can affect the quality but not change the test. What about lithium?
Just asking since my results do show DNA matches at 2nd-3rd cousins on both maternal and paternal lines and way beyond but nothing on people closely related to me who’ve also tested. I’m certainly related to my parents given other DNA matches but even a maternal full uncle shows as a cousin and a paternal full uncle (dad’s paternal twin) and his daughter (my first cousin) don’t show at all, although I have matches with all the people who’ve tested a couple more generations back. Weird.
Can’t find anywhere if lithium (all I currently take for BP) is doing something weird to my DNA showing less cMs or if I just am an anomaly. Lol.
*correction: oops - I meant dad’s FRATERNAL twin.
So I've been depressed and have had severe anxiety for 3 years. Antidepressants make me hypomanic (kinda) and triggers unstable mood. I don't fit in the usual description of bipolar, but there is definitely something not right about the way i react to antidepressants - feeling high, warm, racing thoughts x 100, gets overly chatty etc.
I've tried the following moodstabilizers
Abilify (made me hypomanic)
Seroquel (made me hypomanic)
Depakote/valproate (still taking)
This depression is killing me, but my p.doc. won't prescribe me lithium. Tried two different doctors. What are your thoughts?