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So my pdoc and I finally came to the conclusion that it is a strong likelihood that my dose of 150mg Lamictal is causing my agitation/anxiety by keeping me in a perpetual hypomanic state (with some nice mixed features thrown in there).  I've cycled through the AAP's and AC's plus I'm on a healthy dose of lithium (1200mg.... don't ask my levels, I don't remember) and none have been able to tamp down the agitation sufficiently enough.  As much as I think the Lamictal has helped my depression, I can't be happy with how agitated I feel (if that makes sense). The plan is to cut it in half for the next two weeks until I see him again, and then reassess from there.  So really, I'm starting at 75mg starting tomorrow morning.  Has anyone had any experience with tapering off their Lamictal?  Did you relapse into depression?  If so, how long did it take?  Did anyone find that their anxiety improved after stopping Lamictal?

Any feedback is appreciated.

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It took me more than 4 weeks but I was at 200... I can’t speak to the immediate effects because my med situation was quite complex and I was IP, but long term over the taper I didn’t experience any major mood shifts

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On 7/30/2020 at 6:58 PM, Arj72 said:

So my pdoc and I finally came to the conclusion that it is a strong likelihood that my dose of 150mg Lamictal is causing my agitation/anxiety by keeping me in a perpetual hypomanic state (with some nice mixed features thrown in there).  I've cycled through the AAP's and AC's plus I'm on a healthy dose of lithium (1200mg.... don't ask my levels, I don't remember) and none have been able to tamp down the agitation sufficiently enough.  As much as I think the Lamictal has helped my depression, I can't be happy with how agitated I feel (if that makes sense). The plan is to cut it in half for the next two weeks until I see him again, and then reassess from there.  So really, I'm starting at 75mg starting tomorrow morning.  Has anyone had any experience with tapering off their Lamictal?  Did you relapse into depression?  If so, how long did it take?  Did anyone find that their anxiety improved after stopping Lamictal?

Any feedback is appreciated.

Coming off Lamictal, I actually became more anxious and agitated during the titration process (titrating up as well). Lamictal is interesting that the experience titrating up and down seems to be pretty much the same for me at least. Anxiety and agitation no matter what direction the dose is going. As for a relapse into depression afterwards? No, because I was on other medications maintaining that, which leads me to my question: Have you ever tried valproate? Even in low doses, it can be very helpful for mixed states. Not sure if it would be necessary to take with lithium, but my combo of Depakote+Rexulti does wonders for me when it comes to irritability, agitation, and sleep.

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