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Anyone try Cytomel/ T3 (off-label, for fatigue/depression?)


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Has anyone (without a clinical thyroid disorder) tried Cytomel and had benefit with depression & fatigue? It seems most docs are resistant to trying it due to the possible heart/ bone density side effects.

Even when it comes to thyroid disorders, There are some circles that disagree with the TSH lab ranges (what is "acceptable") and that TSH may not be good indicator of thyroid function for everyone anyway...

I know T3 is rarely prescribed (even for ppl with thyroid issues). But I also read that in a few studies, folks with treatment-resistant depression (with no thyroid issues) can also benefit from using T3 as an add-on or "booster".

 

 

Edited by Blahblah
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5 hours ago, Blahblah said:

I know T3 is rarely prescribed (even for ppl with thyroid issues). But I also read that in a few studies, folks with treatment-resistant depression (with no thyroid issues) can also benefit from using T3 as an add-on or "booster".

Maybe you already found this one....... Here's a clinical study, that showed mood scores improved in depressed people who augmented an SSRI with T3:      https://pubmed.ncbi.nlm.nih.gov/16483669/

Here is a similar study, but this one was done only with female patients: https://pubmed.ncbi.nlm.nih.gov/17289154/

I have personally never heard of T3 being used as a augment for depression........Maybe many pdocs are reluctant to do it for the reasons you listed (possible heart/bone density side effects)...........Perhaps you could bring it up with your pdoc, and get some feedback on it......Never hurts to ask.

Edited by CrazyRedhead
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My pdoc uses it in MDD when there is poor response to multiple classes of antidepressants on their own and also in BP depression- there was a study (im too tired to look sorry) that it can be an effective adjunct that doesn’t cause mania, which helps lower the need to resort to antidepressant use, which we all know is a hotly debated subject. For me no response up to 75mcg over Several months, and I think adderall masks smaller changes in energy level. However this doesn’t mean much cuz nothing really helps on its own for my depression, so probably a bad frame of reference 

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Thanks @Iceberg How are you doing these days? I was wondering if anyone here had personal experience trying it. From my research, I've seen it isn't often used, but it's worth trying. and supposedly it works quickly (if it does work)

That's interesting you had no response at that dose. You're right though, maybe it depends on the other meds (or stimulants) you are taking (or if you have gut/absorption issues) & whether there's the possibility of an existing subclinical thyroid issue...

Edited by Blahblah
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I also for some unknown biological reason am not a good responder to meds. Meaning not that they don’t help, but that I often don’t feel them at all even when a normal person would be hit hard (best examples ambien, trilafon, trileptal, restoril, Vraylar and rexulti but there are others) 

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