DoubleU Posted July 10, 2021 Share Posted July 10, 2021 I know these do some things with dopamine, but that's the limit to my understanding. Has anyone taken these two together, and if so what were the results. Do they work on same pathways? I guess I'm asking would they be friends or foes? Thank you for any input. Link to comment Share on other sites More sharing options...
Iceberg Posted July 10, 2021 Share Posted July 10, 2021 Wellbutrin is thought to inhibit reuptake of dopamine and norepinephrine, meaning prolonged exposure of receptors to those neurotransmitters, causing the mood enhancing effect. Vraylar is a dopamine partial agonist (at D3 receptor and also D2) which means it modulates the level of dopamine action in the brain leading to antipsychotic and some antidepressant possibilities. Vraylar may also affect some serotonin receptors which can help depressive symptoms, which is a mechanism. Shared by other atypical antipsychotics 1 Link to comment Share on other sites More sharing options...
Complicated toad Posted September 2, 2021 Share Posted September 2, 2021 I see the original post is a little old, but I'll throw in an anecdote, I started Vryalar a couple weeks ago and I've been on Wellbutrin for years. So far, it's going well, in fact I'm feeling better than I've felt in many months. Link to comment Share on other sites More sharing options...
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