DoubleU Posted July 10 Share Posted July 10 I know these do some things with dopamine, but that's the limit to my understanding. Has anyone taken these two together, and if so what were the results. Do they work on same pathways? I guess I'm asking would they be friends or foes? Thank you for any input. Quote Link to comment Share on other sites More sharing options...
Iceberg Posted July 10 Share Posted July 10 Wellbutrin is thought to inhibit reuptake of dopamine and norepinephrine, meaning prolonged exposure of receptors to those neurotransmitters, causing the mood enhancing effect. Vraylar is a dopamine partial agonist (at D3 receptor and also D2) which means it modulates the level of dopamine action in the brain leading to antipsychotic and some antidepressant possibilities. Vraylar may also affect some serotonin receptors which can help depressive symptoms, which is a mechanism. Shared by other atypical antipsychotics 1 Quote Link to comment Share on other sites More sharing options...
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