hollow log Posted April 10, 2006 Share Posted April 10, 2006 Hey, has anyone experienced depression while ramping up seroquel, or ramping it up too quickly? I've been going up from 100mg to 200mg and as I started to hit 175mg I started to get depressed... been getting teary etc. It could be other factors, but I've experienced depression when ramping up seroquel too quickly before... so hmmm, anyone have similar experiences? Tonight I'm gonna be takin it easy, and dropping the dose a bit. edit: I should also say that I've been going up to 200mg to help with the paranoia I've been experiencing.... it's been getting pretty bad. I think people are talking about me a lot. And, errr, I think people are saying bad shit. I haven't noticed a major improvement when ramping it up..... maybe some improvement. I don't know what else to do besides increasing the seroquel to help with this. Any ideas? Link to comment Share on other sites More sharing options...
Velvet Elvis Posted April 10, 2006 Share Posted April 10, 2006 If it's social anxiety SSRIs can help as well. At higher doses seroquel should have a bit of an anti-depressant effect. I suppose the histamine blocking which causes the sedation could also cause some depression at first but I'd think that once the dose is high enough to have an effect on norepeniphrine this would be negated. Link to comment Share on other sites More sharing options...
hollow log Posted April 10, 2006 Author Share Posted April 10, 2006 SSRIs are pretty much out of the equation with me... wouldn't be game to try that lot again for fear of getting hypomanic. maybe I am experiencing the sedation/depression thing... I'm not on a really high dose.... I know after awhile on a steady dose I sense the anti-depression effects... *shrug* will take it easy anyhow, and increase it slowly. If it's social anxiety SSRIs can help as well. At higher doses seroquel should have a bit of an anti-depressant effect. I suppose the histamine blocking which causes the sedation could also cause some depression at first but I'd think that once the dose is high enough to have an effect on norepeniphrine this would be negated. <{POST_SNAPBACK}> Link to comment Share on other sites More sharing options...
chimpmaster Posted April 11, 2006 Share Posted April 11, 2006 Its really common to mistake the initial seroquel "zombieitis" for depression early on in treatment. It can make you feel tired all the time, low energy, lack of or increase in appetite, generally a little jittery and a little weird. The good news is that once you reach a stable dose, after a couple of weeks these symptoms go away for most people. The solomnence effects of seroquel pretty much go away at higher doses for most people; Im on 1500mg and it doesnt knock me around too much any more. Link to comment Share on other sites More sharing options...
whatsgoingon Posted April 12, 2006 Share Posted April 12, 2006 I don't know about Seroquel specifically, but antipsychotics in general can make you depressed. It has happened to me in the past. Link to comment Share on other sites More sharing options...
Miguel A. Posted April 15, 2006 Share Posted April 15, 2006 Yup. Just upped to 400mg seroquel, moving up 25 or 50 mg every week. Had a crushing depression - not zombiefication, with which I'm familiar with from early in the treatment. Not sure if this had to do with upping the dosage, though - it was helping me with depression thus far. Link to comment Share on other sites More sharing options...
borzage Posted April 15, 2006 Share Posted April 15, 2006 My pdoc was pushing me up at like 100mg each month. Every time the dose increased, I'd have a week of being a zombie, and eventually I started to get depressed because I had no life. Zombies, contrary to their glamorous media image, have no life. The last time he wanted to increase it again, I said NO, THANKS. Now I'm holding at 300 and my life has been better. I generally like the medicine, I think it helps to quell ruminations and paranoid thoughts. It does seem to make me anxious about an hour after I take it, before I fall asleep, but that could just be me. And then there's the thing about sleeping 13 hours every night... Kinda nice, kinda lame. Link to comment Share on other sites More sharing options...
hollow log Posted April 15, 2006 Author Share Posted April 15, 2006 Yeah my shrink says that the recommendations for increasing seroquel are pretty nuts. Some ppl can handle going up quickly on it... ppl that are reeeeally psychotic or manic. She said it's like they "suck it up" really quickly. Whereas with hollow log, he's only really a bit of an insomniac, with anxiety, and some paranoid thoughts, so increasingly it quickly knocks him about.... I think it's more than just a zombie thing... it really does make you depressed.... or the zombie thing makes you depressed. Anyhow, I decreased my dose a bit and I'm feeling fine again. Link to comment Share on other sites More sharing options...
Miguel A. Posted April 16, 2006 Share Posted April 16, 2006 My pdoc was pushing me up at like 100mg each month. Every time the dose increased, I'd have a week of being a zombie, and eventually I started to get depressed because I had no life. Zombies, contrary to their glamorous media image, have no life. He increased you in 100mg steps, you mean? or increased weekly or bi-weekly so that in average you were going 100mg/month? Jumping from say from 200mg to 300mg or from 300mg to 400mg sounds pretty crazy and ugly-reactions-inducing judging by what I feel with 25mg/50mg increments... Link to comment Share on other sites More sharing options...
whatsgoingon Posted April 16, 2006 Share Posted April 16, 2006 Yeah my shrink says that the recommendations for increasing seroquel are pretty nuts. Link to comment Share on other sites More sharing options...
chimpmaster Posted April 17, 2006 Share Posted April 17, 2006 Yeah my shrink says that the recommendations for increasing seroquel are pretty nuts. Some ppl can handle going up quickly on it... ppl that are reeeeally psychotic or manic. She said it's like they "suck it up" really quickly. Whereas with hollow log, he's only really a bit of an insomniac, with anxiety, and some paranoid thoughts, so increasingly it quickly knocks him about.... I think it's more than just a zombie thing... it really does make you depressed.... or the zombie thing makes you depressed. Anyhow, I decreased my dose a bit and I'm feeling fine again. I must be a seroquel dyson then (1500mg/day). Link to comment Share on other sites More sharing options...
robotlove29 Posted April 19, 2006 Share Posted April 19, 2006 Did anyone else have the Seroquel starter pack?? It ramped me up from 25mg to 800 in a matter of 8 days!! Ha! Just thought I'd add that. I didn't know if that was fast since I had no prior experience with it but I actually took it pretty well aside from the sedation factor (zzzzzzzzzzzz....). Link to comment Share on other sites More sharing options...
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