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My med compliance lacks. I tend to skip once a week, roughly. And extend days out beyond 24 hours

 

I want to discuss the prospect of depot injections with care team

 

I'm always scared to ask med questions

 

I don't know how to start the discussion

 

Dr M also thinks that the risperidone is not pulling its weight as well anymore. And mentioned exploring other options

 

Table 1 Comparison of atypical LAI antipsychotic medicines PBS listed for maintenance treatment of schizophrenia2, 14-16
 

Risperidone

Olanzapine

Paliperidone

Aripiprazole

Available doses

Vial kits: 25, 37.5, 50 mg

Vial kits: 210, 300, 405 mg

Prefilled syringe: 25, 50, 75, 100, 150 mg

Vial kits: 300, 400 mg

Injection interval (weeks)

2

2 (210, 300 mg)

4 (405 mg)

4

4

Injection site

Deltoid or gluteal (maintenance)

Gluteal

Deltoid (initiation)

Deltoid or gluteal (maintenance)

Gluteal

Oral medicine required after first injection

Yes – continue for 3 weeks

No

No

Yes – continue for 2 weeks

Recommended starting dose*

25 mg

Varies according to the oral dose initially taken

150 mg (day 1) + 100 mg (day 😎 administered in deltoid

400 mg

Recommended maintenance dose

25 mg

Varies according to the oral dose initially taken

75 mg

400 mg

 

Limited options. And it is mostly the more manageable dosing that I am interested in. But with paliperidone being 4 weeks and administered in arm, I'm wondering if it is different enough to the risperidone to work better?

 

 

 

 

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14 hours ago, DogMan said:

My med compliance lacks. I tend to skip once a week, roughly. And extend days out beyond 24 hours

 

I want to discuss the prospect of depot injections with care team

 

I'm always scared to ask med questions

 

I don't know how to start the discussion

 

Dr M also thinks that the risperidone is not pulling its weight as well anymore. And mentioned exploring other options

 

Table 1 Comparison of atypical LAI antipsychotic medicines PBS listed for maintenance treatment of schizophrenia2, 14-16
 

Risperidone

Olanzapine

Paliperidone

Aripiprazole

Available doses

Vial kits: 25, 37.5, 50 mg

Vial kits: 210, 300, 405 mg

Prefilled syringe: 25, 50, 75, 100, 150 mg

Vial kits: 300, 400 mg

Injection interval (weeks)

2

2 (210, 300 mg)

4 (405 mg)

4

4

Injection site

Deltoid or gluteal (maintenance)

Gluteal

Deltoid (initiation)

Deltoid or gluteal (maintenance)

Gluteal

Oral medicine required after first injection

Yes – continue for 3 weeks

No

No

Yes – continue for 2 weeks

Recommended starting dose*

25 mg

Varies according to the oral dose initially taken

150 mg (day 1) + 100 mg (day 😎 administered in deltoid

400 mg

Recommended maintenance dose

25 mg

Varies according to the oral dose initially taken

75 mg

400 mg

 

Limited options. And it is mostly the more manageable dosing that I am interested in. But with paliperidone being 4 weeks and administered in arm, I'm wondering if it is different enough to the risperidone to work better?

 

 

 

 

It can be better for some people, but you’d probably have to determine that with oral dosing first 

interestingly there is also a paliperidone  3 month and even a 6 month 

Edited by Iceberg
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