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15 minutes ago, deeschmee said:

Basically there is some evidence that SSRIs can slow white blood cell multiplication (reduced immune reaction), reduce cytokine signaling (these are chemicals released in the body to cause inflammation and activate parts of your immune system) and trigger the death of some white blood cells (apoptosis) which would overall lower the level of immune reaction in your body.

the second part basically says they aren’t sure why this happens but they list a few very complicated potential reasons that SSRIs do this 

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6 hours ago, deeschmee said:

And knowing full well you are not able to give any medical advice, could this possibly ignite or show signs of an auto-immune disease? Or possibly give a positive ANA result? 

Honestly I have no idea, and I don’t think the arrival gave a definitive answer 

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  • 3 weeks later...
On 11/5/2022 at 7:56 PM, deeschmee said:

Background: The old hypothesis of depression is that serotonin levels are low, so you inhibit the transporter (SERT) which is responsible for clearing serotonin from the synapse and then that increases activation of serotonin receptors like in Step A of Figure 1 in that link. The new hypothesis is that depression is really an inflammatory condition in which our own immune system creates a hostile inflammatory environment that our brain doesn't like, and this may be what actually makes us depressed.

Speed up to the present day and a lot of genome-wide analysis says that the mutations in our white blood cells are what people with clinical depression have in common, among others. But we know that the SERT is present significantly on the surface of lymphocytes (white blood cells), so inhibiting it and increasing serotonergic activation seems to calm down not just our brains but also our immune systems.

On 11/6/2022 at 9:33 AM, deeschmee said:

And knowing full well you are not able to give any medical advice, could this possibly ignite or show signs of an auto-immune disease? Or possibly give a positive ANA result? 

No, on the contrary as I indicated, depression is more likely to cause signs of an auto-immune disease than the antidepressant that probably makes those issues better, according to this article.

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