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I have finally convinced my UK pdoc to let me try Prozac (soon to be lexapro) and wellbutrin.

Serotonin syndrome is possible with this combination, but extremely unlikely.

If you want to be ultra careful, read up on the SS symptoms.

I really would not worry about it though.

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Wellbutrin acts on norepinephrine and dopamine. The Lexapro is highly selective for serotonin. Ne'er the twain shall meet.

I've been on 450 mgs Wellbutrin XL and 50 mgs Zoloft for over a year now with no ill effects (unless you count the purple pustules with wiry orange hairs growing out of them.)


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