sunburnt22 Posted August 24, 2006 Share Posted August 24, 2006 i'm on lexapro 10 mg, and wellbutrin XL 150 mg. i've been on them for quite a long time but still experience persistent fatigue and mild depression. i've tried raising the dosages on them but to no avail. the increased lex makes me more depressed and the increased wellb. makes me more tired, disrupts my sleep, etc. unfortunately i'm pretty med sensitive. it seems to help when i add low doses of diff. meds. so what could i add to this mix? low dose of a diff. SSRI maybe? Link to comment Share on other sites More sharing options...
null0trooper Posted August 24, 2006 Share Posted August 24, 2006 increased wellb. makes me more tired, disrupts my sleep, etc. unfortunately i'm pretty med sensitive. I've read that sometimes the noradrenaline (NA) reuptake inhibtors can actually incur NA depletion, which in turn could make you more tired. Have you tried supplementing with an amino acid precursor like phenylalanine or tyrosine? (No guarantees, and increased protein consumption may work as well or better) And if the current meds are able to cut the depression back to mild depression, regular exercise might do the trick (Then again, if you're already running marathons and swimming a few miles per day before breakfast, then reducing the exercise might be helpful) Link to comment Share on other sites More sharing options...
sunburnt22 Posted August 24, 2006 Author Share Posted August 24, 2006 increased wellb. makes me more tired, disrupts my sleep, etc. unfortunately i'm pretty med sensitive. I've read that sometimes the noradrenaline (NA) reuptake inhibtors can actually incur NA depletion, which in turn could make you more tired. Have you tried supplementing with an amino acid precursor like phenylalanine or tyrosine? (No guarantees, and increased protein consumption may work as well or better) And if the current meds are able to cut the depression back to mild depression, regular exercise might do the trick (Then again, if you're already running marathons and swimming a few miles per day before breakfast, then reducing the exercise might be helpful) actually, that's the problem, my fatigue is really bad. i'm able to function, but exercise only makes things worse...and yes, i've exercised long enough to make sure it's not just an initial adjustment period to exercise where you sometimes get more tired. Link to comment Share on other sites More sharing options...
mrsloony Posted August 24, 2006 Share Posted August 24, 2006 i was on wellb and prozac. adding a low dose of lithium made a huge difference for me- really helped the depression. also you could try something like provigil for the tiredness- or ritalin. Link to comment Share on other sites More sharing options...
Loon-A-TiK Posted August 26, 2006 Share Posted August 26, 2006 what i'm going to suggest may sound far-fetched or weird, but you could consider talking to your pdoc about either atypical antipsychotics or mood stabilizers. both can be used alone or with ADs for depression patients. i know several depressed people on Lithium, and it has made a big difference for them. I've also heard of depressed people taking Lamictal or Seroquel. It may be worth a shot. Especially the mood stabilizers. The AAPs tend to make you tired, at least at first. Or they did it to me. I also got EPS. Loon Link to comment Share on other sites More sharing options...
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