Unregistered Posted November 3, 2006 Share Posted November 3, 2006 This flies in the face of everything we thought we knew about antidepressant induced mania in bipolar... The report indicates that in a recent study SSRI's reduced both depression (obviously) but also mania in patients with untreated bipolar II Link to comment Share on other sites More sharing options...
Velvet Elvis Posted November 3, 2006 Share Posted November 3, 2006 That was a trial of ten patients. A number of bp folks can take SSRIs just fine. There is just a risk involved. They probably looked for other factors such as agitation which would indicate an increased likelihood for SSRI induced mania and excluded those people from the study. All this really tells us is that people who don't have a manic reaction to SSRI don't have a manic reaction to SSRIs. Link to comment Share on other sites More sharing options...
AirMarshall Posted November 3, 2006 Share Posted November 3, 2006 I would chalk this up as being more in the realm of being a supporting study that underpins what is already already known, but probably not directly documented. Some people can have a switch to mania from taking an SSRI, but it is not predictable, nor diagnostic for Bipolar disorder. It is curious that they found ten rapid cyclers, who had never been treated before with any meds to use for the study. I'm not sure how well using rapid cyclers represents the much larger body of bipolar sufferers. Hopefully these folks will continue this work and figure out how to predict who has reacts badly to AD's. Thanks for finding this! a.m. p.s. May I suggest that it would be kind if you would put even a one or two sentence summary of the article, so people can decide whether it is of interest, without forcing them to follow links off site and then have to read the article? Link to comment Share on other sites More sharing options...
Unregistered Posted November 3, 2006 Author Share Posted November 3, 2006 Added a one liner, AM. Good idea. Actually, if you go to the root of that site, there's quite a lot of interesting research stuff there on bipolar. Link to comment Share on other sites More sharing options...
LikeMinded Posted November 4, 2006 Share Posted November 4, 2006 I've always figured that... <captain obvious> BPIIs tolerate SSRIs better than BPIs. </captain obvious> Though this study pretty much has zero statistical significance, hopefully it'll encourage more study into the biological basis of BP-II. (<rant>I never felt that BP-I and BP-II had a terrible lot to do with each other anyways, save for episodes of different moods....</rant>) Link to comment Share on other sites More sharing options...
Unregistered Posted November 7, 2006 Author Share Posted November 7, 2006 Sorry, Captain Obvious, but when I was put on fluoxetine, I lost the plot completely and very quickly. I eventually had to be coaxed out from under the table where I was hiding from everything. Me and SSRI's do not see eye to eye. Link to comment Share on other sites More sharing options...
LikeMinded Posted November 7, 2006 Share Posted November 7, 2006 Sorry, Captain Obvious, but when I was put on fluoxetine, I lost the plot completely and very quickly. I eventually had to be coaxed out from under the table where I was hiding from everything. Me and SSRI's do not see eye to eye. Captain Obvious was just being relative. I personally know more than one BP2 who does (well, did) not play nice with SSRIs. But, judging by the overall assumptions made by the poster here, I assume that BPIs do not take SSRIs well at all. Many (if not a majority) of BP2s work reasonably well with SSRIs. You're obviously one of the many exceptions. You're making the valuable point that not every BP2 should be treated the same, it's a heterogenous disorder in and of itself (BPI notwithstanding). Link to comment Share on other sites More sharing options...
Loon-A-TiK Posted November 10, 2006 Share Posted November 10, 2006 just simply on the topic of BP1 people taking SSRIs- i've taken both paxil and lexapro without causing any manic or hypomanic reactions. currently i take WB and am looking at switching back to paxil, as soon as my pdoc will let me...lol (he says i switch meds too much, and i really do!). Link to comment Share on other sites More sharing options...
resonance Posted November 10, 2006 Share Posted November 10, 2006 I have seen a paper stating that the SSRI -> hypo/mania reaction happens in 30-40% of people with bp. (It did not state 1 vs 2). Link to comment Share on other sites More sharing options...
Dee Posted November 10, 2006 Share Posted November 10, 2006 I thought I loved Effexor. Turned out it was euphoric mania and I kept upping the dose. Lots of fun until I started rapid cycling and having mixed states. It was a short love affair for this BP1 chick. Link to comment Share on other sites More sharing options...
Loon-A-TiK Posted November 10, 2006 Share Posted November 10, 2006 i should actually say i don't know, because i've always taken SSRIs with a mood stabilizer. i got slightly manic when i started paxil ages ago, and it went away so we never worried about it, and it never came back. Link to comment Share on other sites More sharing options...
Unregistered Posted November 12, 2006 Author Share Posted November 12, 2006 Yeah, Loon, I think the issue here is SSRIs without a mood stabiliser. Me + fluoxetine - lamotrigine = ugly mess. Link to comment Share on other sites More sharing options...
LikeMinded Posted November 12, 2006 Share Posted November 12, 2006 Yeah, Loon, I think the issue here is SSRIs without a mood stabiliser. Me + fluoxetine - lamotrigine = ugly mess. You reminded me of something. For me, taking an SSRI/SSNRI results in nothing (except perhaps increased silicovaginosis)... to get them to work, I need a 'bad guy serotonin receptor' blocker, as well as a mood stabilizer, which du jour is Lamictal. Link to comment Share on other sites More sharing options...
Unregistered Posted November 12, 2006 Author Share Posted November 12, 2006 You reminded me of something. For me, taking an SSRI/SSNRI results in nothing (except perhaps increased silicovaginosis) What?? Is this what you're talking about. No wonder I quit the SSRI's... Link to comment Share on other sites More sharing options...
LikeMinded Posted November 12, 2006 Share Posted November 12, 2006 You reminded me of something. For me, taking an SSRI/SSNRI results in nothing (except perhaps increased silicovaginosis) What?? Is this what you're talking about. No wonder I quit the SSRI's... Whoops, sorry about that, there was a misunderstanding. By the prefix "silico-", I meant silicon dioxide (i.e., the form of dirt we know as sand), and not the polymer known as silicone. Link to comment Share on other sites More sharing options...
Unregistered Posted November 13, 2006 Author Share Posted November 13, 2006 and there was I, just thinking you'd gone hypersexual... ;-) Link to comment Share on other sites More sharing options...
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