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Combining meds and side effects


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I was wondering if it is possible that combining meds could cause different side effects than if you were taking the drugs alone. Or if say,  drug 1 could have certain side effects that only happen when combined with drug 2. Say, if drug 1 was taken alone or with a different med/s then that certain side effect/s wouldn't happen. Sorry if this just makes no sense.

  ;)

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