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I am up to 300mg of seroquel. I have a mix of 50mg pills and 300mg pills now. My problem is I have to dose myself with it 3 or 4 times a day. Like, 100 in the morning, 50 at lunch, 50 at dinner, and 100 in the evening. This goes along with 4-6mg of klonopin, and 45mg of remeron. I don't get any sedaiton from it, I haven't had any appetite gain, in fact I now have no appetite at all. It works, it works really well actually. I like it better than zyprexa in the fact it isn't so sedating. Anyway, my pdoc told me I shouldn't do it this way, that I should only need a dose at night and in the morning. Am I just metabolizing it fast? I'm going to have to find a solution soon, before I run out of 50mg pills. I can only chop the 300mg in half, chopping the halves in half results in fireworks of pill. It just seems weird, I don't know. I don't want to quit the med I just want to know if this is normal or anything.

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How much are you supposed to take total per day?

I think it has a really short halflife in the blood but hangs out in the brain for longer.

DD takes it three times a day - 200 mg. in the a.m., 200 mg. at dinner, and 300 mg. at bed. It seems to work better for her this way.

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How much are you supposed to take total per day?

I think it has a really short halflife in the blood but hangs out in the brain for longer.

DD takes it three times a day - 200 mg. in the a.m., 200 mg. at dinner, and 300 mg. at bed. It seems to work better for her this way.

Yeah it does have a short half life, and 3 x daily dosing is common. It reaches peak plasma concentration in 4 hrs, and then gradually flows out of the system. I take mine at 8am (300mg), 12pm (600mg) & 4pm (300mg) which seems to work well enough (and I am prescribed to do it this way).

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