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Depakote and increased agitation

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I'm hitting the bottom of the barrel of mood stabilizers here. I'm back on Depakote and it sucks. Somehow it's making me more agitated, anxious and up (obviously not a good kind of up). Not the same, exactly, as akathisia. But similar. It happened the last time I went on Depakote, but I thought it was because we pushed the dose too fast.

But it seems to be a feature of even 250 mg. I am sure it is the Depakote because before I switched to the ER, I was doing sprinkles and could literally feel the sweaty bouncy heart-palpitating raciness kick in. Even taking it the morning, I'm so wound up at night that my sleep is pretty unrefreshing. I also have bouts of disorientation and just wanting to minimize all sensory input. I hate this.

So it's a good old fashioned paradoxical reaction. Or rather: one of the <5% side effects from the PI sheet. I don't really have a choice but to tough it out for a while. (The rest of the barrel now contains verapamil and gabitril.) But I'm wondering if anyone else got this as a transient start-up effect. It would be nice to have some sort of hope for a light at the end of the Depakote tunnel here.

Or is there some sort of augmentation? Is my brain being starved of dopamine or my body of some amino acid? I feel royally fucked by my body/mind, so any advice is greatly appreciated.



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I had some not so great reactions to Depakote when I was taking it.

It made me feel sort of similar to what you are describing.

I eventually had to stop taking it because it was doing much more harm than good.

I don't know what else you could try or if this feeling will pass. I know I pushed it too far and tried to stay on it too long. I started at 250 for two weeks and went up to 500 briefly to see if it would help. It didn't work out, but the fact that it was suggested I continue taking it means that it probably is a transient effect in some people. That's what my nurse was hoping.

It didn't work for me, but increasing the dosage slower might make a difference this time. I don't know how long you were planning on waiting before increasing the dose. It may take a while.

But you do sound terribly frustrated and these side effects are rough. Don't let yourself stick with it for too long if it isn't doing anything.


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