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zoloft's effect on dopamine


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i've read (on CB and elsewhere) that zoloft has a slight effect on dopamine reuptake inhibition. i'm trying it again after a couple of months, but the last time i took it i had to stop because i would get really bad headaches, or get launched into dysphoric moods if i had any caffeine in combination with it. its my suspicion that i can't combine it with caffeine because of the slight dopamine affinity - which just generally amplifies dopamine signalling in my brain, or by some other mechanism causes things to go a little haywire. this time i'm going to try to take it without any caffeine - but i still am a little curious/concerned about the dopamine effect, and whether that has caused anybody else to have to stop taking zoloft? did anyone else experience problems with anger or sudden drop in moods on it? i'm curious if people's experiences on zoloft have been different than with the other ssri's.

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Cavet:

I don't remember seeing anything about in vivo studies in humans. It's important to note that receptor bindings is the determining factor when it comes to the effect of a med, so without that information we're pretty much left with idle speculation. Just knowing that it has an effect on DA without knowing where and how is about as usefull as knowing the color of the pill.

http://www.journals.elsevierhealth.com/per...011453/abstract

http://www.preskorn.com/books/ssri_s3.html

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