provigil and maoi's

[sunny]

I went to the p-doc's the other day I asked about provigil for day time fatigue He says he wouldnt recomend me taking it with an maoi and my anxiety condition I work 2 jobs I am currently taking nardil and just started abilify todays my first day ill have to see how it goes I hope it works risperdal didn't work for me I know maoi's are contridicted with alot of meds just wanted to see if anyone was on the provigil and maoi combo or it is most definetly a no go I have a little bit of caffine during the day try to keep it low it helps but just wears me out after

current meds nardil 15 mg 2 times a day 10 mg of abilify

supplemented with multi vitamin

[AirMarshall]

Howdy, welcome!

Here is a drug interaction check from http://www.drugs.com

a.m.

You have searched for drug interactions between the following drugs: Provigil, Nardil, Abilify

Please note: only generic drug names are displayed.

Drug-Drug Interactions

phenelzine and aripiprazole (moderate Drug-Drug)

Description:

MONITOR:

Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT:

During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them. Patients should also be advised to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

modafinil and aripiprazole (moderate Drug-Drug)

Description:

MONITOR:

Coadministration with drugs that are inducers of CYP450 3A4 may decrease the plasma concentrations of aripiprazole, which is partially metabolized by the isoenzyme. According to the manufacturer, carbamazepine (200 mg twice a day), a potent CYP450 3A4 inducer, decreased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of both aripiprazole (30 mg once a day) and its active metabolite, dehydro-aripiprazole, by approximately 70%.

MANAGEMENT:

Pharmacologic response to aripiprazole should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the aripiprazole dosage adjusted as necessary. The manufacturer recommends that aripiprazole dosage be doubled when carbamazepine is added to therapy, and additional dosage increases be based on clinical evaluation. No dosage recommendations are available for concomitant administration with other CYP450 3A4 inducers.

[Velvet Elvis]

Yeah. Anything that could boost NA levels could get scary. Aren't you supposed to avoid caffeine as well?

Isn't parnate supposed to be more stimulating than nardil?

[null0trooper]

Yeah. Anything that could boost NA levels could get scary. Aren't you supposed to avoid caffeine as well?

From the PI sheet I have: "AVOID LARGE AMOUNTS of coffee, tea, cola drinks, or chocolate." (The all-caps words are verbatim)

I would think chocolate poses more of an actual risk from MAO-B inhibition and its phenethylamine content. IME, 5 mg selegiline makes caffeine

hit harder than 20 mg parnate, but either way - unless you are slamming down the high-caffeine "energy drinks" you'll be uncomfortable from the

physical stimulation effects long before you'll be in danger from elevated BP.

[Guest Guest_sunny_*]

thanks for all the info and interactions that seems like a well informed site abilify's sedation has gone down after a few weeks of use so thats a good thing! there are a lot of contridictions with the maoi ie: food , other prescriptions I think it works good for me for my depression, social anxiety so ill stick with that I think my pdoc is going to increase my abilify next time I see him so ill see how that goes it seems to help my bad thoughts a bit not as frequent

anyone else on an antipsychotic + nardil regimen let me know

[crispy40]

Update Nov 2017. The use of modafinil with MAO inhibitors seem to be mere common now and free of side effects.

I take parnate (30mg) and just started modafinil 200mg (AM) for adjunct treatment as parnate was not fully successful and was sedating for me (low energy and feeling weak on my legs).

So far so good although I feel a little jittery. My psychiatrist told me she has several patients on fairly high dosage of the 2 meds.

Personally, I am looking at alternatives such as Kratom which is well worth looking at. There is scant data on the safety of using kratom with MAO inhibitors and plenty of STRONG WARNINGS not to do it (risk of serotonin syndrome). Stopping MAOIs for 14 days at least is what is recommended.

IF you are NOT on an MAOI, Kratom seems very safe and effective on depression, anxiety, pain, even ADD. It should be tried with a low dose (about 1 teaspoon of powder) on an empty stomach and NOT combined with opioids. educate yourself on it by going to independent sites like kratom bible.