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Nortriptyline - Blood plasma levels

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Just a couple of quick questions about nortriptyline, even though I am not on nort at the moment, if anyone can answer them.

-  Is it absolutely necessary to have a blood test to check the blood plasma levels of nortriptyline if you are taking a dose of either 50mg or 75mg?

-  Can either 50mg or 75mg be an effective therapeutic dose? 

-  Would nortriptyline be as effective as or more effective than Wellbutrin, combined with a SSRI like Zoloft

I am struggling to find the right combination for me to address my anergic depression (probably more adhedonia than no energy) with some anxiety but more "nameless dread". 


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