Spuffy Posted January 2, 2008 Share Posted January 2, 2008 I know that I just opened a poll thread, but I'm extremely worried about this--probably needlessly. I am on the 12 mg Emsam patch. Is the likelihood of experiencing extra-pyramidal side effects from Geodon affected at all when an MAOI is involved? Maybe I should ask if anyone has experience on an atypical AP and an MAOI together. Or, is there anyone who understands D2 binding, pathways? I don't. Any explanations help. Any thoughts you might have on the combination are welcome. I'm sorry to sound so desperate. Link to comment Share on other sites More sharing options...
quiet storm Posted January 2, 2008 Share Posted January 2, 2008 I dont see why you would have a bigger risk. I think it would probably be less actually over something like an ssri or snri or nothing at all since the maoi is actually making extra dopamine available. EPS is usually caused by too little dopamine, not too much. Link to comment Share on other sites More sharing options...
null0trooper Posted January 3, 2008 Share Posted January 3, 2008 I dont see why you would have a bigger risk. I think it would probably be less actually over something like an ssri or snri or nothing at all since the maoi is actually making extra dopamine available. EPS is usually caused by too little dopamine, not too much. With Parnate or Nardil I would worry, as Geodon has some serotonin and noradrenaline reuptake inhibition (RxList): MAO-A inhibition + serotonin reuptake inhibition is usually a bad thing. However, MAO-B (Emsam) inhibition generally doesn't affect serotonin levels, and combining some noradrenaline reuptake inhibition isn't anywhere near so dire as serotonin syndrome. If anything the Emsam should strongly reduce the EPS without touching D2 binding. Link to comment Share on other sites More sharing options...
quiet storm Posted January 3, 2008 Share Posted January 3, 2008 Well I was strictly talking about EPS. I wasnt aware of the serotonin action of geodon. I just know that like other atypicals it antagonizes dopamine receptors. You agree with me that it would probably reduce EPS. Link to comment Share on other sites More sharing options...
null0trooper Posted January 3, 2008 Share Posted January 3, 2008 Well I was strictly talking about EPS. I wasnt aware of the serotonin action of geodon. I just know that like other atypicals it antagonizes dopamine receptors. You agree with me that it would probably reduce EPS. I found a mention of it on RxList when I looked it up. I'm rarely quite sure which atypical is which, and some of them are just odd anyway. Link to comment Share on other sites More sharing options...
Spuffy Posted January 3, 2008 Author Share Posted January 3, 2008 Thank you both for the reassurance. I get adverse effects at small dosages of so many drugs that I worry whenever I begin one. You're very kind to answer so quickly! Link to comment Share on other sites More sharing options...
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