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is this dumb or am i wrong? wellbutrin for psychosis?


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dont ask me why i'm asking this. this would violate someones privacy if i tell.

so basicly lets say some hypothetical person has psychosis and depression, and he hasn't even found the right antipsychotic yet.

and he has been prescribed wellbutrin for his depression.

wellbrutin is a dopamine reuptake inhibitor. it increases dopamine.

dopamin excess is one of the very well stablished theories of psychosis.

i think the doc who does this is a complete idiot.

what do you think? am i wrong?

i encourage you to even ask your pdoc the next time you go to him and post what he says. it's serious shit. i have the feeling that someone may go down the shitter soon because of this.

cheers

polar bear

edit: oh btw:

[link=http://ajp.psychiatryonline.org/cgi/content/full/156/12/2017-a" target="_blank]http://ajp.psychiatryonline.org/cgi/conten...l/156/12/2017-a[/link]

[link=http://www.ncbi.nlm.nih.gov/pubmed/15610958"'>http://www.ncbi.nlm.nih.gov/pubmed/15610958" target="_blank]http://www.ncbi.nlm.nih.gov/pubmed/15610958[/link]

wikipedia: "There is evidence of several neuropsychiatric symptoms associated with bupropion in patients with depression, including delusions, [link=http://en.wikipedia.org/wiki/Hallucination" target="_blank]hallucinations[/link], [link=http://en.wikipedia.org/wiki/Psychosis" target="_blank]psychosis[/link], concentration disturbance, [link=http://en.wikipedia.org/wiki/Paranoia" target="_blank]paranoia[/link], and confusion."

[link=http://en.wikipedia.org/wiki/Bupropion#Adverse_effects"'>http://en.wikipedia.org/wiki/Bupropion#Adverse_effects" target="_blank]http://en.wikipedia.org/wiki/Bupropion#Adverse_effects[/link]

[link=http://www.mentalhealth.com/drug/p30-b04.html#Head_4"'>http://www.mentalhealth.com/drug/p30-b04.html#Head_4" target="_blank]http://www.mentalhealth.com/drug/p30-b04.html#Head_4[/link] read the precautions

[link=http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-828457"'>http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-828457" target="_blank]http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-828457[/link] yes. it even causes psychosi sometimes even when the person has no history of psychosis

[link=http://ajp.psychiatryonline.org/cgi/content/abstract/142/12/1459" target="_blank]http://ajp.psychiatryonline.org/cgi/conten...act/142/12/1459[/link]

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If Wellbutrin acted as an antipsychotic it would be in the class of meds called antipsychotics. Theoretically, if depression is causing psychosis, it stands to reason that resolving the depression would resolve the psychosis. However, antidepressants take a while to work and a lot of damage can occur in the meantime. I'd get your friend to a different doctor.

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Son of a bitch, I wrote out a long ass answer and lost it. Here we go again:

I am not the best person on the board to answer this question, but I think I know what the pdoc is thinking.

Wellbutrin hits nicotinic acetylcholine receptors. Some theorize (the researchers at Eli Lilly, for example) that tinkering with acetylcholine will help many people with MI. Notice how many people with MI smoke? That could be part of the reason why...That and it helps attention.

This article is a few years old, but it should give you the idea. This theory has been floating around for awhile:

http://www.schizophrenia.com/nicotine.benefits.htm

And another:

http://www.schizophrenia.com/sznews/archives/000879.html

And another:

http://www.schizophrenia.com/szresearch/archives/001061.html

And one more:

http://www.schizophrenia.com/sznews/archives/000102.html

Per NIDA, Wellbutrin does not exacerbate Schizophrenia symptoms:

http://www.drugabuse.gov/NIDA_notes/NNvol20N5/Bupropion.html

Is this person still taking an antipsychotic, even though he and the pdoc are having trouble finding the magic one? If so, this may not even be an issue.

I use Schizophrenia as an example as my mother has Undifferentiated Schizophrenia - both positive and negative symptoms. She smokes like a fucking chimney. And her desperate-ass psychiatrist has prescribed her damn near anything and everything. Even Ritalin, which hits dopamine receptors. It didn't help her, but it didn't hurt her either.

I also use this example because as far as I'm concerned, all of this MI shit is somehow related. A lot of the same genes and everything. I did a Genogram for a class and included MI as one of the things I mapped. My family is a walking DSM...

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the person is NOT taking an antipsychotic.

btw, i asked my pdoc (who is an extraordinarily good one)

and he said "it's kind of OK if the person is taking an antipsychotic, but if not, it's kind of dangerous"

p.s.: i know welbutrin is not an antipsychotic. if i didnt i'd be a retard for posting a thread like this ;)

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