betcsu Posted September 1, 2008 Share Posted September 1, 2008 i have been prescribed, at different times, with klonopin & tranxene. whats the difference? theyre both in the benzo family from what i can tell, but i'm not sure how theyre different. the tranxene is 7.5mg & the klonopin is .5mg (i think). can anyone tell me how they compare or contrast? thanks in advance! Link to comment Share on other sites More sharing options...
SUEzie Posted September 1, 2008 Share Posted September 1, 2008 I think there may be a topic board at the top of this forum board on Benzos ("Chill Pills") above, that somewhat enumerates the differences between benzos. I checked the first post in that section, and it looks to me like Traxene has a longer half-life, and generally works faster. Beyond that, I am not sure of the differences. Wish I had more to add, and hopefully someone will write in soon w/more information - if what you are seeking is info re:Personal experiences with these drugs. I wish you well, - Susan Link to comment Share on other sites More sharing options...
scream_phoenix Posted September 1, 2008 Share Posted September 1, 2008 i just recently asked my pdoc to switch me from klonopin to tranxene. part of the decision was made after reading on here that klonopin takes an hour to start working in your system. i'm not sure if that's true or not klonopin is definitely strong and does the job but sometimes it just starts me on an emotional up and down as it wanes from my system, and i really didn't want to become dependent on it every day. i have this handy benzo comparison chart that i printed out years ago that has conversions on all the benzos. it looks like 0.25 mg of Clonazepam (Klonopin) = 10 mg of Tranxene so klonopin is pretty strong. klonopins half life is 34 hrs whereas tranxene's is 100. i thought klonopin is the one i read that is inactive until it is metabolized, but it is actually tranxene. i'm not sure if that' sgoing to make a huge difference or not, but tranxene is going to stick around in your system longer and from my experience exert its effects at a slower milder rate. Link to comment Share on other sites More sharing options...
LikeMinded Posted September 2, 2008 Share Posted September 2, 2008 Tranxene (clorazepate) seems to be big on the safety margin (the manufacturer states that doses over 120mg have not resulted in major disaster in humans, but please don't try and add another data point to that statistical figure). It is also quickly dispatched by your liver, but this is useful since it's converted to nordiazepam (a relative of diazepam, aka Valium). It could be this conversion that limits how toxic Tranxene can be, since anybody who takes an OD of Tranxene would have to wait for his liver to convert all the Tranxene into nordiazepam for effects to occur, and that the liver can only convert things so quickly. Klonopin is the one of the two benzos you've mentioned that I've taken... actually, I'm on it PRN right now for occasional muscle stiffness (not an approved use but it works for me) and for dealing with my parents (again, not approved for that, but works for me). To tell the truth, also, I didn't know anything about Tranxene until I got onto this thread and looked it up. Klonopin is treated in a sort of complex manner in your body, but the big thing about it is that it has a "half-life" of 30-40 hours (again, this is what the manufacturer says on the prescribing information sheet). This means, after taking your first dose, after the drug hits its peak concentration in your blood (the mfr. says this takes 1-4 hours), it then takes 30-40 hours for that level to drop to half as part of the drug is dispatched via your liver and/or your body's more conventional mechanisms of expelling things into the environment. The manufacturer doesn't talk about whether the liver's byproducts of Klonopin are active or not. So there's my two mg... Link to comment Share on other sites More sharing options...
betcsu Posted September 2, 2008 Author Share Posted September 2, 2008 thanks everybody! i tried to read thru the posted comparisons, but couldnt quite figure it out. you all have helped tremendously! thanks again! Link to comment Share on other sites More sharing options...
SUEzie Posted September 2, 2008 Share Posted September 2, 2008 Well - in that very top post here is the "Benzo section" they are listed there under their generic names, on that comparison chart. I dunno, (maybe Silver, herrfous or somebody else can help out here )- but I am pretty sure that Klonipin is listed under the generic name Clonazepam. There are some things I didn't understand altogether when I read that chart, too, but got a few valuable bits of info. Silver, Air Marshall, herrfous and other folks who take bezos can probably explain more, if you want to know. I think that Traxene is listed under the generic name Chlorazepate Dipotassium (sp?) in that first chart, too. If you didn't know that already, maybe that helps? I wish you well, - Susan Link to comment Share on other sites More sharing options...
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