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Amitriptyline and Weight Gain


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I haven't filled in my prescription yet. I'm supposed to take 10mgs a day to help with sleep and pain. I saw that one of the side effects is extreme weight gain. I'll only be on 10mgs a night. What are the chances of my gaining weight? Has anyone taken this small amount?

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yes, some years ago. The amount prescribed just for sleep is so low... I didn't gain any weight and honestly would be very surprised if you did. My sister also took it for several months recently and was fine. Try not to fret about it - I hope it gives you some decent rest!

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I took it years ago for chronic back pain. It didn't really help with the back pain but it DID make me sleep, but very soon I found that 10mgs didn't do it, and in the end I could take between 5 and 8 tablets and still no sleep, so I knocked it on the head.

Unfortunately also it's used as an anti-depressant and when I found I had to take more to make me sleep, the anti-depressant qualities started kicking in and then I went hypomanic.

Here's hoping it works OK for you though ;)

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I've never taken Amitriptyline, but I do take Remeron, which has a similar side effect profile, and I worried about this a lot before filling my script, but I haven't gained much weight at all so far (about 6 weeks in) so I just wanted to reiterate that YMMV - if you try it and you start to gain weight, you can always stop taking it, but you may very well not gain any. If you're REALLY concerned, just watch your diet - the carb cravings can be killer, though I stopped getting them so much within a few weeks. If you take it and then go straight to bed, you don't really have time to stuff yourself with sweets. That's what I've been doing.

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  • 7 months later...
Guest veronicacherry

I haven't filled in my prescription yet. I'm supposed to take 10mgs a day to help with sleep and pain. I saw that one of the side effects is extreme weight gain. I'll only be on 10mgs a night. What are the chances of my gaining weight? Has anyone taken this small amount?

Yes, I started in Dec. Needed something to help me sleep. Dealing with the a breakup and school. Well since then I went from 267 to 305 as of today.

Be careful .

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  • 6 months later...

I took between 150-250mg/day for years. I did gain weight but I can't really say that it was from the amitriptyline.

just about to take amitriptyline and a little apprehensive. was on risperdal three years ago and gained nearly 2 stone as a result.

will this have the same effect?

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The weight gain issue with TCA's has more to do with carb cravings than metabolic changes. Put a lock on the sugar bowl. There is a hangover effect with the sedation. Don't plan to do any aerobic exercise until noon for the first few weeks. It does attenuate for most people. The dosage you've been prescribed is very low, so you may not incur any funky side effects. The biggest cautions with amitriptyline have to do with QT prolongation (I trust you don't have a pacemaker) and its' really screwy elimination (something like 19 hours to 41 days). The latter is a serious issue for folks at the high end of the dosing range. I have know a couple of people who have inadvertently overdosed while taking it as prescribed. Not a good scenario. But again, your dosage is way low to make this a concern.

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  • 5 months later...
Guest Cereta Hardy

I took it for one week and it wouldn't allow me to get up and work. It made the pain go away cause I sleep through it. After it wears off feels like a bad hangover. Taken it for sciacia nerve pain.

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  • 3 weeks later...
  • 2 months later...

I am taking 50 mg of amitriptyline once a day at bedtime to prevent migraines. I have only been on it for about 3 weeks and so far I think I have gained some weight but I haven't weighed myself yet.

I think I've gained some weight because I can tell by the way my clothes are fitting and the size of my boobs. I just feel bloated and gross. The medicine doesnt knock me out at night but I find it alot harder to get up and out of bed in the morning. I will be talking to my doctor about maybe trying something else that wont cause increased appetite and weight gain.

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  • 2 weeks later...
  • 2 weeks later...

I've been on Amitriptyline for 5 months now; when I was only taking 10-50mg I don't think I gained much if anything. They just moved me up to 100mg at night for my Migraines at I know I have gained a large amount of weight just in the last month, I am bloated, exhausted & its not even helping my migraines.

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  • 2 months later...
Guest Kristina

I had been on 10-20 mg per day for insomnia. I did not gain weight during this time. About a month ago I found that it was no longer helping me sleep so my dosage was increased to 40-50 mg. In the past month I have gained about 8 pounds without changing my eating and exercise habits. I am frustrated as the amitriptyline helps for insomnia, but I am worried about the weight gain!

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