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Seroquel can't make me sleep anymore


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For the past 3 or so weeks, Seroquel has not been helping me sleep at all. I'm taking 50mg. The other traitor, Cymbalta, would not let me stay asleep because I get crazy night sweats so I have to lower the temperature to stop it then raise it again because it's too cold. I take only 60mg of Cymbalta but the side effects are so inconvenient. I don't even want to get started on what happens to me when I miss a dosage.

I also get panic attacks every so often, can't breathe, numbing fingers, and so on and so forth.

Sorry, I just really had to complain. My pdoc cannot be reached for comment (as usual).

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Hey,

About the Seroquel - the first time I took 50 mg for a couple of nights, it worked like a charm. Then, when I went back to it a few months later, nothing. I called pdoc and she told me to keep bumping up the dose until it made me sleep, as long as I stayed under 200 (which is apparently considered the max dose that is okay for insomnia). So I tried 25, 50, 100, 150 and 200, and it turns out that only 150 mg makes me sleep. Nothing above, and nothing below.

For lots of people, tiny doses of Seroquel are perfect for sleep, but some of us need a different dose. Might be something to talk to pdoc about.

Also, even if the Seroquel is no good anymore, there are tons of other possibilities. If you can't sleep because you're too anxious, you might want to consider trying a benzo (Ativan, Klonopin etc.). There's also the z-compounds (Ambien, Lunesta, Imovane etc.) and a couple of anti-depressants you can take at a very low dose - trazodone or remeron - that will knock you out.

I'm sorry to hear about the panic attacks and the Cymbalta crap, though - sounds like you've got a lot of aggravation going on. Good luck getting a hold of your pdoc.

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My experience with Seroquel is that I have developed a tolerance over the years. I started with 12.5mg a night and that lasted for ages but eventually I had to go up to 25mg a night. The 25mg worked for about half a year untill I had to go up to 50mg which lasted a few months. I then went to 100mg which lasted about a month then 150mg lasting a couple of weeks, 200mg had no greater effect but as I got up to 300mg a night it started working again. I have been on 300mg for a few months now and it's the dose I need.

I have been lucky with Seroquel, nothing else will put me out (except remeron which will want to make me sleep 24 hours a day).

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  • 2 months later...

You doctor might want to try increasing the dosage. Note that the saturation point for the drowsiness is at 200mg. I'm glad you were able to sleep while on 75mg ;) . try having to stay awake while taking 400mg twice per day >.> .

Edited by Swamp56
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I take 100mg during the day and 400mg at night. Usually I can slowly drift off to sleep at night once I take my seroquel. It's nice because it makes me feel like I've been up for a few days straight and then I relax and sleep. The only downside is when I am manic even if I take my seroquel it has zero effect on me, I can still stay up for days.

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  • 2 weeks later...

I was up to 400mg at one point when I was really in the crapper but I never slept any better than I did when I was just on 50-100mg for sleep(I currently take 50mg with lunesta). I feel ya with the sweating on cymbalta. When I was on it(120mg) I sweated at night like a one legged man at an asskicking contest. I was having to wash the sheets every few days.

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  • 8 years later...

Does anyone take alot of seroquel and you can't sleep. I take 800 mg per night along with 4 benadryls and this is what my Psych told me to do and I can stay awake for hours.  It just doesn't do anything for me.  She said someone on that dosage at 145 lbs should be basically in a coma.  

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On 8/29/2017 at 8:56 PM, Chrmd said:

Does anyone take alot of seroquel and you can't sleep. I take 800 mg per night along with 4 benadryls and this is what my Psych told me to do and I can stay awake for hours.  It just doesn't do anything for me.  She said someone on that dosage at 145 lbs should be basically in a coma.  

Seroquel is less sedating at higher doses. Did your doctor give you 800mg specifically for sleep?

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6 minutes ago, Swamp56 said:

Seroquel is less sedating at higher doses. Did your doctor give you 800mg specifically for sleep?

Yes she gave me that and told me to add 4 benadryl on top of that.  She told me it should basically knock me out.  It doesnt phase me. 

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  • 3 months later...

I take 200 mg of Seroquel in the AM and 800 at night plus 10 of Ambien and a couple of Trazodone just for fun. I have never heard of Rozerem.  Is it new? I have been without alcohol for a week now and I am so manicky. Valium doesn't touch it. I just keep thinking that a couple glasses of wine would make me feel so much better.

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