Aurochs Posted May 7, 2009 Share Posted May 7, 2009 Schizophrenia drug licensed from Titan wins FDA OK Wikipedia on Fanapt - kind of a shitty article but it has links to some studies. This drug was just approved on Wednesday, May 6, so I don't have any other information at this time (PI sheets, patent data, etc). Additional info will be posted as it becomes available. Link to comment Share on other sites More sharing options...
gizmo Posted May 7, 2009 Share Posted May 7, 2009 Thanks for the article. Just one more in a long line of medications to possibly try if the ones I'm taking don't cut it anymore. Though the sleepiness side effect worries me (it's a hot button topic for me, as it's the one side effect I *always* seem to get) I'll be interested to see some real world experience come in later this year when it's released. Link to comment Share on other sites More sharing options...
tryp Posted May 7, 2009 Share Posted May 7, 2009 Fanapt? God, that makes me think of some sort of weird milkshake flavor. Or a Domino's pizza. Or Fandango. NOT an anti-psychotic. That's interesting, though. I wonder how it will do for the off-label brain squirrels. Link to comment Share on other sites More sharing options...
Phoenix_Rising Posted May 7, 2009 Share Posted May 7, 2009 Fanapt? God, that makes me think of some sort of weird milkshake flavor. Or a Domino's pizza. Or Fandango. NOT an anti-psychotic. That's interesting, though. I wonder how it will do for the off-label brain squirrels. . I thought it sounded like something bad that happens if you get too close to a fan....Fanapt. Yeah, I wanna hear about the off-label uses, too. Aurochs: Thanks for sharing the info. Link to comment Share on other sites More sharing options...
netsavy006 Posted May 7, 2009 Share Posted May 7, 2009 Here's the current drug's website. Doesn't have really much anything now but I'm sure it will expand over the coming months: http://www.fanapt.com Link to comment Share on other sites More sharing options...
tryp Posted May 8, 2009 Share Posted May 8, 2009 Aww, it's pretty Link to comment Share on other sites More sharing options...
Aurochs Posted May 8, 2009 Author Share Posted May 8, 2009 Aww, it's pretty More importiantly, it has a PI sheet. I'm gonna have fun with this. =P Thanks netsavy, that's gonna be real helpful. Link to comment Share on other sites More sharing options...
netsavy006 Posted May 8, 2009 Share Posted May 8, 2009 Thanks netsavy, that's gonna be real helpful. No problem. Happy to help. Link to comment Share on other sites More sharing options...
maybetinymaybesad Posted May 8, 2009 Share Posted May 8, 2009 is it actually novel? or is it another invega? Link to comment Share on other sites More sharing options...
tryp Posted May 8, 2009 Share Posted May 8, 2009 It seems like it's novel - I don't see any mention of a predecessor, and the chemical name doesn't look similar to any of the current AAPs. ETA - yup, I looked up the scientific studies on Iloperidone, and the studies call it "a novel atypical antipsychotic" Link to comment Share on other sites More sharing options...
gizmo Posted May 8, 2009 Share Posted May 8, 2009 Wow, the hits just keep on coming on the PI sheet with this drug. You got the TDs, the weight gain, the QT prolongation, the raised prolactin levels, dysphagia, a 12% chance it's going to knock you out (or at least make you crash on the couch all day), and you have to retitrate to the drug after only a 3-day lapse off of it.. so be careful if you get the flu. LOL, it looks like the PI sheet for my zyprexa, and that's really saying something. All I can say is that it will be interesting to see what the first people taking it have to say about it. Link to comment Share on other sites More sharing options...
Phoenix_Rising Posted May 8, 2009 Share Posted May 8, 2009 I'm fairly new to the world of AAPs, so I may be full of shite here. It looks to me that Fanapt doesn't affect cholesterol and triglycerides as much as the other AAPs. (Although, as gizmo pointed out, it does seem to affect just about everything else) Similarly, there were no medically important changes in triglyceride and total cholesterol measurements (from the PI sheet) Am I understanding this correctly? Link to comment Share on other sites More sharing options...
Aurochs Posted May 8, 2009 Author Share Posted May 8, 2009 I'm fairly new to the world of AAPs, so I may be full of shite here. It looks to me that Fanapt doesn't affect cholesterol and triglycerides as much as the other AAPs. (Although, as gizmo pointed out, it does seem to affect just about everything else) Similarly, there were no medically important changes in triglyceride and total cholesterol measurements (from the PI sheet) Am I understanding this correctly? I'm not so sure. The Abilify PI sheet says the same thing, and most of the others list hypertriglyceridemia or hypercholeteremia as infrequent or rare side effects. I'll try to dig up some more research on the subject, but right now I feel comfortable saying that only time will tell what this actually means. Link to comment Share on other sites More sharing options...
fuchsia groan Posted May 8, 2009 Share Posted May 8, 2009 the chemical name doesn't look similar to any of the current AAPs. Sort of a tangent, but how do drug names work? (The real names, not the smarmy brand names they come up with.) Iloperidone sounds a lot like risperidone... Link to comment Share on other sites More sharing options...
Aurochs Posted May 8, 2009 Author Share Posted May 8, 2009 International Nonproprietary Names are determined by a committee within the World Health Organization, based on a system of stems and modifiers that are intended to describe the chemical structure. For instance, iloperidone has the same stem as risperidone because they're chemically similar. Clozapine and olanzapine are chemically similar as well (both are benzodiazepine derivatives). And so on. EDIT: If you're REALLY interested, there's more information than you'd ever want to know here. Link to comment Share on other sites More sharing options...
Generica Posted May 9, 2009 Share Posted May 9, 2009 Anyone know why this class of drugs has all the same serious side effects? Everything new just seems to have the same problems. Is there research going on to develop novel drugs outside of this class, avoiding these side effects? Link to comment Share on other sites More sharing options...
fuchsia groan Posted May 10, 2009 Share Posted May 10, 2009 Thanks, Aurochs! I'd been wondering about that. I'm such a nerd. Thanks for adding in the link too. Link to comment Share on other sites More sharing options...
Aurochs Posted May 10, 2009 Author Share Posted May 10, 2009 I'm fairly new to the world of AAPs, so I may be full of shite here. It looks to me that Fanapt doesn't affect cholesterol and triglycerides as much as the other AAPs. (Although, as gizmo pointed out, it does seem to affect just about everything else) Similarly, there were no medically important changes in triglyceride and total cholesterol measurements (from the PI sheet) Am I understanding this correctly? I'm not so sure. The Abilify PI sheet says the same thing, and most of the others list hypertriglyceridemia or hypercholeteremia as infrequent or rare side effects. I'll try to dig up some more research on the subject, but right now I feel comfortable saying that only time will tell what this actually means. This study classifies antipsychotics according to their risk for hyperlipidemia. Judging from the PI sheet, Fanapt appears to be a low-risk compound, along with Abilify, Geodon, and Risperdal. Link to comment Share on other sites More sharing options...
Aurochs Posted May 10, 2009 Author Share Posted May 10, 2009 Anyone know why this class of drugs has all the same serious side effects? Everything new just seems to have the same problems. Is there research going on to develop novel drugs outside of this class, avoiding these side effects? I'm not really sure how to go about answering your question, since there's no real agreement on what makes an atypical antipsychotic in the first place. Weight gain seems to be associated with histamine H1 and serotonin 5-HT1A and 5-HT2C blockade; since serotonin receptor blockade seems to be essential for atypicality, we're not likely to get away from that one until someone figures out how to selectively ignore those receptors. (And even then, we may find that they have other effects that are necessary to block...) I don't know enough to tell you why it prolongs the QT interval. As for research, yes, there is some research into non-D2-blocking agents. Selective α2C blockers are being looked at, acetylcholine modulators, and metabotropic gultamate agonists are all being looked at, just to take a few examples. It'll just take a while to see anything like that on the market. Link to comment Share on other sites More sharing options...
Silver Posted May 16, 2009 Share Posted May 16, 2009 The MacGuffin's post on Fanapt says most of what I wanted to say, but better. Link to comment Share on other sites More sharing options...
dancesintherain Posted November 3, 2009 Share Posted November 3, 2009 It looks like it's actually going to be released this upcoming year... http://www.washingtonpost.com/wp-dyn/content/article/2009/11/01/AR2009110101846.html in case anyone was starting to hear about it. Link to comment Share on other sites More sharing options...
Recommended Posts
Archived
This topic is now archived and is closed to further replies.