lurker53 Posted July 4, 2009 Share Posted July 4, 2009 My pdoc prescribed me Sertaline (generic for Zoloft) in addition to my 150mg of Wellbutrin and .5mg (2x daily) of Klonopin because she said the Sertaline would help with anxiety and often works well with Wellburtin (she said some call it Well-Oft). I started at 50mg per day of Sertaline in addition to the others and didn't notice much of a difference. When she bumped me up to 75mg per day of Sertaline in addition to the others, about five or six weeks in now all I want to do is sleep. I work from home and have become very unmotivated to get any work done, find myself exhausted a lot and the sleeping during the daytime makes me soooooo depressed. I started taking the Wellbutrin and Sertaline in the morning so I decided to switch it to nightime hoping I'd be less tired. That worked a little bit, but I am still unmotivated to do anything and simply want to lay in bed all day. I see my pdoc in a couple of weeks but I am already started to cut back on the Sertaline (now taking 50mg a day). Has anyone experienced this with Zoloft? I don't wake up anxious like I used to, just depressed and lethargic. Not a good trade off for me. Can Zoloft make you more depressed? It's the 4th of July, finally sunny out and I've slept in until 1PM and don't want to do anything. Any shared stories would help me. Link to comment Share on other sites More sharing options...
buddha443556 Posted July 4, 2009 Share Posted July 4, 2009 Probably the Klonopin and Zoloft, there's a CNS interaction warning on those two, the don't drive you're stoned sort of thing. Probably should tell your doc. Link to comment Share on other sites More sharing options...
Nebulous Nurse Posted July 4, 2009 Share Posted July 4, 2009 I'm not sure from your post if the Zoloft is simply sedating which makes you depressed, because it's hard to be alert, active, and productive, or if it is directly increasing your depressive symptoms themselves. I don't want to scare you, but when I was 14, I was placed on a small amount of Zoloft for clinical depression, and it messed me up royally. Within the week, I could hardly walk, couldn't do math, and was about as majorly depressed as I could get. Nothing new happened in my life other than that small dose of Zoloft, and it cost me greatly. I some ways, at 27, I still don't feel I've fully recovered from it, functionally speaking. So I can assure you that Zoloft can indeed make you more depressed, but if it really is more of a sedation issue, than indeed the Klonopin may have something to do with it. Link to comment Share on other sites More sharing options...
JackBQuick Posted July 4, 2009 Share Posted July 4, 2009 Was on Zoloft for 4 years way back when.... I was a raging lunatic/superhero and my mate feared for her safety. Phil Hartman's wife (she had BPII according to the local MSM) was on Zoloft shortly after and ended up killing Phil and herself. From my POV, Zoloft is a shitstorm. I never got "up" from it, just raging angry and seething all the time. And more depressed thanks to Depakote which ballooned me from 170 lbs of rock solid muscle to 220 lbs of flab. I hate both of those fucking meds. Link to comment Share on other sites More sharing options...
Mayteana Posted July 4, 2009 Share Posted July 4, 2009 Zoloft is the only SSRI that didn't sedate me. There's certainly other meds of that class that can be used for anxiety if the sertaline isn't working for you. ~ May Link to comment Share on other sites More sharing options...
lurker53 Posted July 5, 2009 Author Share Posted July 5, 2009 Probably the Klonopin and Zoloft, there's a CNS interaction warning on those two, the don't drive you're stoned sort of thing. Probably should tell your doc.Not sure what a CNS interaction warning is, I tried to google the interaction between Klonopin and Zoloft and the term CNS but didn't find much. Shouldn't my pdoc know that there could be an interaction issue with these two? Link to comment Share on other sites More sharing options...
lurker53 Posted July 5, 2009 Author Share Posted July 5, 2009 I'm not sure from your post if the Zoloft is simply sedating which makes you depressed, because it's hard to be alert, active, and productive, or if it is directly increasing your depressive symptoms themselves. I don't want to scare you, but when I was 14, I was placed on a small amount of Zoloft for clinical depression, and it messed me up royally. Within the week, I could hardly walk, couldn't do math, and was about as majorly depressed as I could get. Nothing new happened in my life other than that small dose of Zoloft, and it cost me greatly. I some ways, at 27, I still don't feel I've fully recovered from it, functionally speaking. So I can assure you that Zoloft can indeed make you more depressed, but if it really is more of a sedation issue, than indeed the Klonopin may have something to do with it.Is Zoloft for anxiety or for depression or for both? The lack of energy, wanting to sleep all the time, not feeling like I want to do anything at all and the lack of motivation has me more depressed than before. I've always had depression issues, but never to the point where I just wanted to sleep all day. That part scares me. Link to comment Share on other sites More sharing options...
buddha443556 Posted July 5, 2009 Share Posted July 5, 2009 Probably the Klonopin and Zoloft, there's a CNS interaction warning on those two, the don't drive you're stoned sort of thing. Probably should tell your doc.Not sure what a CNS interaction warning is, I tried to google the interaction between Klonopin and Zoloft and the term CNS but didn't find much. Shouldn't my pdoc know that there could be an interaction issue with these two? I use drugs.com's Interactions Checker, it's one of the better ones, just remember to add alcohol to list of meds if you're drinking it. I have no idea what your doctor knows but if you don't tell him he wont know you're having a possible interaction (not everyone does). Link to comment Share on other sites More sharing options...
lurker53 Posted July 6, 2009 Author Share Posted July 6, 2009 Probably the Klonopin and Zoloft, there's a CNS interaction warning on those two, the don't drive you're stoned sort of thing. Probably should tell your doc.Not sure what a CNS interaction warning is, I tried to google the interaction between Klonopin and Zoloft and the term CNS but didn't find much. Shouldn't my pdoc know that there could be an interaction issue with these two? I use drugs.com's [link=http://www.drugs.com/drug_interactions.html" target="_blank]Interactions Checker[/link], it's one of the better ones, just remember to add alcohol to list of meds if you're drinking it. I have no idea what your doctor knows but if you don't tell him he wont know you're having a possible interaction (not everyone does). That's a pretty cool tool to use. I don't drink at all so booze doesn't play a part. Have cut down to 50mg per day of Zoloft now and still exhausted. Any idea how long it takes for a person to see a change by reducing the dosage? I'd like to start functioning again. Link to comment Share on other sites More sharing options...
buddha443556 Posted July 6, 2009 Share Posted July 6, 2009 That's a pretty cool tool to use. I don't drink at all so booze doesn't play a part. Have cut down to 50mg per day of Zoloft now and still exhausted. Any idea how long it takes for a person to see a change by reducing the dosage? I'd like to start functioning again. Yes, it's a cool tool however doesn't replace the doctor. Your doctor maybe able to switch you to another med to avoid the problem if of course it is a drug interaction. Reducing the dosage may not be an option either. The elimination half life is 62-101 hours for Zoloft, probably about week-- just a guess. There are SSRI's with shorter half lives. Link to comment Share on other sites More sharing options...
null0trooper Posted July 7, 2009 Share Posted July 7, 2009 Probably the Klonopin and Zoloft, there's a CNS interaction warning on those two, the don't drive you're stoned sort of thing. Probably should tell your doc. One works on serotonin, the other on GABA. I think the checker is really reaching on that one unless: 1) maybe there are reports of respiratory depression with sertraline administered to elderly patients, or 2) someone either coded sertraline as a CYP 3A4,5,7 inhibitor or as a competing substrate If you're not on the max dosage of either one, aren't elderly, and have a healthy liver, you should be OK. I can't see it hurting to ask your pharmacist about it. Link to comment Share on other sites More sharing options...
buddha443556 Posted July 7, 2009 Share Posted July 7, 2009 Probably the Klonopin and Zoloft, there's a CNS interaction warning on those two, the don't drive you're stoned sort of thing. Probably should tell your doc. One works on serotonin, the other on GABA. I think the checker is really reaching on that one unless: 1) maybe there are reports of respiratory depression with sertraline administered to elderly patients, or 2) someone either coded sertraline as a CYP 3A4,5,7 inhibitor or as a competing substrate If you're not on the max dosage of either one, aren't elderly, and have a healthy liver, you should be OK. I can't see it hurting to ask your pharmacist about it. Zoloft maybe sedating in some people (activating in others and just right in the lucky ones). Taking two sedative is never a good idea. Link to comment Share on other sites More sharing options...
Velvet Elvis Posted July 7, 2009 Share Posted July 7, 2009 I've always had good luck with the SSRI-wellbutrin combo. You may want to try a different SSRI. buddah: It matters why they are sedating. Link to comment Share on other sites More sharing options...
Guest Al725 Posted August 10, 2009 Share Posted August 10, 2009 My pdoc prescribed me Sertaline (generic for Zoloft) in addition to my 150mg of Wellbutrin and .5mg (2x daily) of Klonopin because she said the Sertaline would help with anxiety and often works well with Wellburtin (she said some call it Well-Oft). I started at 50mg per day of Sertaline in addition to the others and didn't notice much of a difference. When she bumped me up to 75mg per day of Sertaline in addition to the others, about five or six weeks in now all I want to do is sleep. I work from home and have become very unmotivated to get any work done, find myself exhausted a lot and the sleeping during the daytime makes me soooooo depressed. I started taking the Wellbutrin and Sertaline in the morning so I decided to switch it to nightime hoping I'd be less tired. That worked a little bit, but I am still unmotivated to do anything and simply want to lay in bed all day. I see my pdoc in a couple of weeks but I am already started to cut back on the Sertaline (now taking 50mg a day). Has anyone experienced this with Zoloft? I don't wake up anxious like I used to, just depressed and lethargic. Not a good trade off for me. Can Zoloft make you more depressed? It's the 4th of July, finally sunny out and I've slept in until 1PM and don't want to do anything. Any shared stories would help me. Link to comment Share on other sites More sharing options...
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