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Over the past week I have suffered new depths of paranoia and psychosis which have made me want to take my own life. I went ot my GP and asked him if he would try me on a Typical Antipsychotic called Clopixol at 2mgs. The reason I wanted to try this one is because it is sedating.

I am prescribed a lot of benzos, but I use them very sparingly as I do not want to end up with a benzo habit and I know that benzos dont cure psychosis, they can only calm me a little.

I have found clopixol to be helpful at this small dose. Haldol does not seem to be working anymore. Zyprexa makes me functional. If I didnt take it I would be in a padded cell but it doesnt tackle my core symptoms.

I was going to discuss with my CPN and p-doc the possibility of going onto Clopixol depot (Zuclopenthixol Decanoate) at a low dose to replace the Haldol as I feel that my brain needs to be heavily sedated. Plus this would take away the factor of my mother fucking around with my tablets.

You would not believe the vile ugly content of the voices and the thoughts that come into my head. I feel that they must be put there by the devil. My brain feels like it is running at 500mph when it should be doing 60mph. Clopixol is sedating antipsychotic. Already I feel calmed down.

I have read all the risks of clopixol and I am willing to have my creativity stifled. Academic achievement is hollow if you are as crazy as a box of frogs.

Should I pester my p-doc for this depot? I doubt he'll be keen

blackbird x

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I have been made mellow at 2mgs which is the babiest dose taken at 6am on an empty stomach. Side effects = eye twitching but considering the therapeutic dosages = 10-30mg a day for schizophrenia I think I need to be at about 7mg a day (as an adjunct to Zyprexa) which would work out as an 200mg injection over 28 days.

Side effects would be drowsiness, menstrual disturbances, TD, EPS - all the usual lovely Typical side effects. It is the sedation I am most attracted to as I feel my mind is running too fast. I want to be chemically straitjacketed.

I could get the injections until I start clozaril or as an adjunct.

I dont mean to sound horrible but people like me just dont take clozaril. It conjures up ideas of day centres, support workers, social workers, sheltered accommodation, never getting a job, putting on 100lbs, drooling and basically being very very ill indeed.

I believe I owe it to myself to exhaust all options before I take such a big step.

sorry if I offended anyone but we just don't hear much from clozaril users around here

blackbird x

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I had asked to take this medication at one point, for similar reasons; my brain needs a big, strong cup of stfu, and I would like to find a way out of taking klonopin/imovane if possible. I'm curious if this pans out for you, and how you feel at a stronger dose. I personally couldnt give a tinker's shit about EPS, NMS, or any other three letter combination, if I felt better.

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I have been made mellow at 2mgs which is the babiest dose taken at 6am on an empty stomach. Side effects = eye twitching but considering the therapeutic dosages = 10-30mg a day for schizophrenia I think I need to be at about 7mg a day (as an adjunct to Zyprexa) which would work out as an 200mg injection over 28 days.

Side effects would be drowsiness, menstrual disturbances, TD, EPS - all the usual lovely Typical side effects. It is the sedation I am most attracted to as I feel my mind is running too fast. I want to be chemically straitjacketed.

I could get the injections until I start clozaril or as an adjunct.

I dont mean to sound horrible but people like me just dont take clozaril. It conjures up ideas of day centres, support workers, social workers, sheltered accommodation, never getting a job, putting on 100lbs, drooling and basically being very very ill indeed.

I believe I owe it to myself to exhaust all options before I take such a big step.

sorry if I offended anyone but we just don't hear much from clozaril users around here

blackbird x

I was on Clozaril for a while in 2002, Blackbird, and I get you. It was shit. I drooled, I tripped out, I could barely stagger to the loo. I was a uni student and about to graduate and, clearly, employers wouldn't be deeply empathetic.

I have to say that, over the years as a mentalist on numerous APs and as an outreach mental health person, I have seen good results on some depots. I.e. Depixol as well as Clopixol. Some acquaintances/friends can't deal with the atypicals and swear by the typicals. A friend of mine can only be functional on Pimozide (orap) and another guy I hung out with who i met in hospital years ago said Clopixol kept him well, as did the guy I knew on Depixol.

I have to say I have been suffering intensely on Seroquel for the last few months and WISH I could go back to Sulpiride, a typical AP. Unfortunately, it was literally shaving my bones away due to killing my periods.

Good luck. I have a sneaky feeling a lot of those APs do a lot more than they are credited for. Sure I have seen research proving they aren't much worse either.

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Blackbird--I was just looking at the med list and was reluctant to play amateur psychiatrist...but I was wondering whether you'd ever done a higher lithium dose? if your brain's going super fast, I just wonder if that's at all a manic-like symptom that could be helped out by the mood stabilizer. And I know I've seen people on much higher doses before.

just a thought--sorry if this has already been attempted. I can't help with the typical APs.

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thanks for the replies everyone

Ehygon - I have cut out Haldol from my combination and met with my CPN today. She said to go up to 4mg Clopixol. I will keep you updated as I progress onwards with the dose as to how the stfu factor figues with my brain.

Amy - thank you for instilling confidence in me. I really want clozaril to be a last resort medication. I am so sorry that you cannot go back to Sulpride and you are having such a bad time with Seroquel

dance in the rain - my lithium level is only at 0.3 so its not really doing anything - so you are spot on, I am in dire need of more lithium. Unfortunately the only one who can rx this is my p-doc who is on holiday at the moment. But we shall see next week

I shall keep you all updated on old creaky Clopixol

thanks again

blackbird x

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  • 2 weeks later...

Hey Blackbird

I found something my psych wrote about the old APs here. He is pretty well-known as an academic here and is also doing the BALANCE trial, a series of trials funded by the Stanley Medical Research Institute.

forum.akmhcweb.org/News/AtypicalsUnderScrutinyNYTimes.h - [Cached Version]

Published on: 5/20/2003 Last Visited: 12/16/2007 But a 2000 analysis, by Dr. John Geddes, a psychiatrist at the University of Oxford, created a stir by finding no difference in effectiveness between the two classes of drugs.The study, financed by the British government and published in the British Medical Journal, examined 52 studies comparing atypicals and older drugs.

At the time, some patient-advocacy groups objected to the study, saying it was biased toward the lower-cost older drugs.

In a telephone interview, Dr. Geddes said that, like other clinicians, he had seen patients improve remarkably on the newer medications."But I remember over the last 20 years I had quite a lot of people who did really well on the older ones, too," he said.

Part of what gave the older drugs a bad reputation, Dr. Geddes contends, was that in the past they were given in very high doses that may have made them less effective and increased side effects.Too, he said, many atypicals "were quite new, and it's not good to go spraying around new drugs without knowing about the long-term effects."

...

Eventually, Dr. Geddes said, the two classes of antipsychotic medication may come down to a tradeoff of side effects: The risk of tardive dyskinesia posed by the older drugs versus the risk of diabetes.

"It's not up to me to say, is it?"Dr. Geddes asked.

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