PBF Posted September 3, 2005 Share Posted September 3, 2005 Hi. I've been on Depakote 750mg/day for a few years now and it has helped a great deal despite pain in the ass side effects. Take that with celexa, seroquel and low doses of xanax as needed (for bipolar II). The worst Depakote side effect is fatigue, especially in the morning after the 250mg dose. I asked my doc if there was anything he could do and he decided that I could try taking my total daily dose before bedtime instead of 500mg hs and 250mg am. Well, this has helped a bit, I'm less tired in the morning/early afternoon. However, I wonder if the once a day dosing is good cause Depakote only has a 16 hour half life. Anybody else take all their depakote in one shot? Any comments or input? Thanx. PS: I also have a similar question about seroquel - at 200mg hs, do I still get a mild antipsychotic effects daytime despite the fact that Seroquel has a 1/2 life of only 8 hours??? PBF Link to comment Share on other sites More sharing options...
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