milkman Posted June 30, 2010 Share Posted June 30, 2010 is it true that risperidone is REALLY potent? one website cant remember which one said risperidone is like haldol on steroids. i guess thats just like saying its REALLY strong. what do you guys think? is it stronger than clozapine(which is meant to be the best antipsychotic)? if NOT stronger than clozapine it must be the second best AP ay?? plz tell me ur thoughts on this... Link to comment Share on other sites More sharing options...
netsavy006 Posted June 30, 2010 Share Posted June 30, 2010 I don't remember much about my experience on risperdal, except that 6 weeks into treatment on .5mg HS, I developed tics and had to stop the medication. Sorry I couldn't be much help. I hope you find the answers your looking for. Link to comment Share on other sites More sharing options...
Velvet Elvis Posted July 1, 2010 Share Posted July 1, 2010 With all the APs potentcy is pretty relative because they have a large dosage rage. Risperdal can go from .25 mgs to over 6 mgs. I take 2mgs which is about in the middle. In terms of its chemical structure and mode of action it's the most "typical" of the atypical APs which might be what the "Haldol on steroids" remark was referring to. It's closer to Haldol than any of the other atypicals. Link to comment Share on other sites More sharing options...
etkearne Posted August 9, 2010 Share Posted August 9, 2010 The reason they said that is because Risperidone, like Haldol, is highly potent on D2 (the receptor that gives the stereotypical antipsychotic effects), but weak on a lot of the other receptors that cause side effects in other AP's, like histamine with Seroquel and muscarinic with Zyprexa. Risperidone has a Ki of 6.31 and Haldol has a Ki of 5.01 on the D2 receptor. Roughly translated, the lower the Ki, the more raw potency an agent has at a receptor. It doesn't mean it is more effective, though. Clozapine has a Ki of 125.89, and is generally considered in the top echelon of effective AP's. Link to comment Share on other sites More sharing options...
ehygon Posted August 11, 2010 Share Posted August 11, 2010 potency relates to the dose required to achieve the desired result. risperdal comes in low dosages because it does not take much of the drug to acheive results. i think you're interpreting "potency" as "effectiveness". That's a lot harder to judge because studies often contradict one another, and unless you've got three centuries to review them all, you're SOL. Link to comment Share on other sites More sharing options...
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