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ADs and Working Out?


Guest energie

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OK, according to rxlist

The mechanism of action of REMERON® (mirtazapine) Tablets, as with other drugs effective in the treatment of major depressive disorder, is unknown.

Evidence gathered in preclinical studies suggests that mirtazapine enhances central noradrenergic and serotonergic activity. These studies have shown that mirtazapine acts as an antagonist at central presynaptic ╬▒2 adrenergic inhibitory autoreceptors and heteroreceptors, an action that is postulated to result in an increase in central noradrenergic and serotonergic activity.

Mirtazapine is a potent antagonist of 5-HT2 and 5-HT3 receptors. Mirtazapine has no significant affinity for the 5-HT1A and 5-HT1B receptors.

Mirtazapine is a potent antagonist of histamine (H1) receptors, a property that may explain its prominent sedative effects.

Mirtazapine is a moderate peripheral ╬▒1 adrenergic antagonist, a property that may explain the occasional orthostatic hypotension reported in association with its use.

It's the H1 antagonism that makes you sleepy. It's an antihistamine. It makes you sleepy but on the bright side you won't have any allergy problems while you're on it. That maxes out at a relatively low dose. As you increase the dose the Alpha-1 (noradreniline) antagonism ramps up, making it more peppy. It might be possible to help boost the effect on NA by taking NA precursors such as l-tyrosine which we have for sale in the crazystore:

http://astore.amazon.com/crazyboards05-20/detail/B000GFSV28

http://astore.amazon.com/crazyboards05-20/detail/B000ELTDAS

L-tyrosine is big with the fitness crowd anyway. I forget why. Search body-building blogs and see what you can find out.

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I've taken AD's before and didn't have problems with energy levels. Probably 'cause I was manic, but whatever. Most of the newer ones shouldn't be sedating. I agree with VE - 45 mg should help. The noradrenaline kicks into high gear at that point, which should give you the boost you need.

L-tyrosine is popular with the fitness crowd because it (drum roll) offsets fatigue. A few members on here take it and have had success. I just started it - I'll let you know how it goes.;)

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It doesn't say anything about l-tyrosine on there that I can see. Taking B-6 and folic acid along with l-tyrosine will help with its conversion though, and that's got the folic acid.

ETA: That review at criticalbench listed some body building compounds that contain it. It might be best to take it as an addon though, I'm not sure.

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