crywolf2010 Posted October 27, 2010 Share Posted October 27, 2010 i have schizophrenia. and have been on nearly every antipsychotic on the planet. when i complain to my pdoc that im still paranoid he keeps increasing the dose. BUT ive noticed theres a certain point where increasing the dose doesnt make much of a difference! ill give u an example. i used to be on 1200mg of seroquel(regular). the way i felt on 1200mg is the same way i felt on 1000mg. so i mean yes if you are on a low dose and you increase it you will notice an improvement in your symptoms BUT if you are already on a high dose and you go higher it may not make much difference? does anyone else agree with me? what are your thoughts on this? Link to comment Share on other sites More sharing options...
nibblerd Posted October 27, 2010 Share Posted October 27, 2010 I've seen a video in another thread where a guy was explaining what it was like to be on 2400mg of Seroquel, so perhaps it does have more effect at higher doses.. but it just sounded irresponsible of the doctors to me. Like, if you don't respond to a super high dose, why push it higher? Just try another.. Link to comment Share on other sites More sharing options...
tryp Posted October 27, 2010 Share Posted October 27, 2010 The answer to your question is yes - above a certain dose, you're not going to see much more improvement. There are a couple reasons why this happens. One is that you have a finite number of receptors in your brain for the drug to work. So after a certain point, you're going to reach your maximum biological effect. It seems to be variable for different people, though. I know that when I was on Celexa and 30 mg crapped out, going to 40 didn't do jack. But other people go up higher than that and still get an increased effect. Link to comment Share on other sites More sharing options...
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