tryp Posted December 9, 2010 Share Posted December 9, 2010 I had a skim through the literature, and in most studies, it looks like TCAs and SSRIs generally have about the same efficacy. So why are TCAs considered to be something good to try after a patient doesn't respond to SSRIs? Is it just in the hope that, since everyone's brain is different, TCAs will be that person's magic bullet, or is there actually something about them that makes them more likely to work than SSRIs? Link to comment Share on other sites More sharing options...
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