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Researchers found that low levels of a specific peptide correlated with both a generally negative perspective ...

Those with low NPY were more negative both before and after the pain – meaning they were more emotionally affected while anticipating the pain and while reflecting on their experience immediately afterward.

and depression.

Subjects with low-expression of NPY were more likely to suffer depression, it was found.

Theoretically, at least, this could be used as a diagnostic tool, and a means to identify those at risk for developing depression.

http://www.telegraph.co.uk/health/healthnews/8308883/Born-miserable-some-people-genetically-programmed-to-be-negative.html

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