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I have a bottle of doxylamine and I take some when I'm having trouble sleeping. I prefer it to diphenhydramine, because diphenhydramine causes me to wake up feeling depressed. It works the same way as diphenhydramine, so if you are tolerant to that one, doxylamine will probably not work any better.

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Tolerance to doxylamine builds within days, just as with diphenhydramine. There's also a potential for cross-tolerance. Really, doxylamine is best used for treatment of occasional insomnia or jet lag.

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