4ao Posted June 20, 2011 Share Posted June 20, 2011 (edited) ... Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
bpladybug Posted June 20, 2011 Share Posted June 20, 2011 I am happy for you! What a great response. I take 300 mgs, all at night, and it starts to weaken a little in effect at about 22 or 23 hours. If I staggered my dose I could probably manage that. Link to comment Share on other sites More sharing options...
Lost_Wolf Posted June 20, 2011 Share Posted June 20, 2011 I'm glad the Seroquil is doing you some good. As my dr and I are still working on getting me stable I'm gonna ask to try Seroquil on my next visit. I have major depression,anxiety and sleep troubles and I think it will help. Hopefully. I do have to ask what is Depressive rumination? And on yur diagnosis it says TLE....what is that? Dont mean to pry I'm just curious. Link to comment Share on other sites More sharing options...
justme04 Posted June 20, 2011 Share Posted June 20, 2011 (edited) I'm happy that it's working amazingly for you! Edited June 20, 2011 by justme04 Link to comment Share on other sites More sharing options...
tryp Posted June 20, 2011 Share Posted June 20, 2011 I agree with Sylvan - if it's wearing off, you will probably do better if you take it at least twice a day. I take mine twice a day and I get much more consistent coverage. I basically have to do that with every medication I try, or stuff just doesn't last. Link to comment Share on other sites More sharing options...
Anna Posted June 20, 2011 Share Posted June 20, 2011 yes, I also think frequency of dosage rather than increasing dosage would probably work better. I take 200 mg XR seroquel in the a.m. and 600 IR at night. seems to be working. anna Link to comment Share on other sites More sharing options...
Will Posted June 20, 2011 Share Posted June 20, 2011 Good luck crow66. I found that depressive rumination (or, dark obsessive thought) was the most persistent problem impacting my professional career, even though I had recurring problems with mania and more "pure" depression. I self-medicated this part of my illness, at times heavily, with alcohol. For some reason I thought for years that this problem was not part of my illness, but some sort of personal weakness. Anti-depressants didn't help me much and Seroquel seems more effective for this. Lost_Wolf: Can't speak for crow66, but for me depressive rumination = e.g., thinking constantly that I have made a catastrophic mistake (and going to my office in the middle of the night to resolve it -- and as soon as I resolve that "mistake" another one will occur to me by the time I get back home) or thinking that some catastrophe will befall my children. In short, persistent and dominating thoughts of impending doom. Link to comment Share on other sites More sharing options...
enlightened_plutonian Posted June 20, 2011 Share Posted June 20, 2011 I take 600mg of Seroquel XR at (should be) 10:30pm at night, but admittedly lately I've been taking it at 11pm. Well suppose better late than never. I don't feel it wearing off myself, but maybe I do get that a little bit when I have to convince myself that I need to take it to make sure my thought control does not return. But for me I think that stress is more responsible for my symptoms than what time I take my meds. I'm glad it is working for you though. I've had a massive improvement in my anxiety levels since going on Seroquel. Link to comment Share on other sites More sharing options...
4ao Posted June 21, 2011 Author Share Posted June 21, 2011 (edited) ...., Edited February 20, 2020 by 4ao Link to comment Share on other sites More sharing options...
Anna Posted June 21, 2011 Share Posted June 21, 2011 Crowe66, be careful with the immediate release seroquel. It can make you drowsy enough not to function, and I'm not kidding about that. Plan not to drive or go to work if you are going to try IR seroquel, like on a weekend or something. I really CANNOT drive on IR quel, and tend do to shit like spilling everywhere, cutting myself when I try to chop vegetables, and things like that. Given the low dose you are on, honestly, if you are feeling wear off sx, I would try taking 50 mg xr in a.m. AND p.m. But that's just me..... Seroquel's full AD and ruminative effects don't usually kick in until about 300 m.g., so you have plenty of room to go up. And if you find yourself overly sedated, you can always split your dose 25/25. However, I'd say watch it with the immediate release quel. Anna Link to comment Share on other sites More sharing options...
4ao Posted June 22, 2011 Author Share Posted June 22, 2011 (edited) ..... On 6/21/2011 at 9:38 AM, Anna said: Â Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
area99 Posted June 22, 2011 Share Posted June 22, 2011 I take 600mg of Seroquel XR at (should be) 10:30pm at night, but admittedly lately I've been taking it at 11pm. Well suppose better late than never. I don't feel it wearing off myself, but maybe I do get that a little bit when I have to convince myself that I need to take it to make sure my thought control does not return. But for me I think that stress is more responsible for my symptoms than what time I take my meds. I'm glad it is working for you though. I've had a massive improvement in my anxiety levels since going on Seroquel. I went on Seroquel xr 50mgs and had a very similar response. Very dramatic decrease in anxiety even after the first dose. Link to comment Share on other sites More sharing options...
SashaSue Posted June 22, 2011 Share Posted June 22, 2011 Thank you Anna for the sedation warning...this is clearly not to be taken lightly. I think that this experience seemed so amazing was in fact more from the knock out, not so much of a quieting of the rumination. Now the sedation isn’t as pronounced the ruminating is returning, not as bad maybe. Dang...things can change so quickly...we'll see where this goes. Premature posting Crow. Crowe66, be careful with the immediate release seroquel. It can make you drowsy enough not to function, and I'm not kidding about that. Plan not to drive or go to work if you are going to try IR seroquel, like on a weekend or something. I really CANNOT drive on IR quel, and tend do to shit like spilling everywhere, cutting myself when I try to chop vegetables, and things like that. Given the low dose you are on, honestly, if you are feeling wear off sx, I would try taking 50 mg xr in a.m. AND p.m. But that's just me..... Seroquel's full AD and ruminative effects don't usually kick in until about 300 m.g., so you have plenty of room to go up. And if you find yourself overly sedated, you can always split your dose 25/25. However, I'd say watch it with the immediate release quel. Anna As Anna said, you have a lot of room to increase your dosage. Link to comment Share on other sites More sharing options...
Anna Posted June 22, 2011 Share Posted June 22, 2011 crowe66 you can go up to 800 m.g. which is the max therapeutic dosage. I'm taking that dose atm, but it's to tamp down a nasty mixed episode. For the rumination, I would say that 50 mg per day is simply not going to be enough.... I'd really look at titrating up (with dr approval, of course) until you hit your seroquel "sweet spot" and I'd also consider splitting doses, a.m. and p.m. for round the clock coverage. My GUESS is, (and this is just a guess) that somewhere around 300-500 you are going to hit the dose you need..... But seroquel clearance is affected by just a bunch of things, including grapefruit and smoking, which most people don't seem to realize, including docs.... Anyway, good luck with it. I find quel to be excellent for ruminations and anxiety, so I would say, given your initial positive experience with it, don't give up on it too quickly, rather, look at dosages and timing. Anna Link to comment Share on other sites More sharing options...
4ao Posted June 26, 2011 Author Share Posted June 26, 2011 (edited) ... On 6/22/2011 at 6:18 AM, Anna said:you Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
4ao Posted June 26, 2011 Author Share Posted June 26, 2011 (edited) ...... Edited February 20, 2020 by 4ao Link to comment Share on other sites More sharing options...
dogsfoot Posted June 28, 2011 Share Posted June 28, 2011 Seroquel almost killed me... Although not really my doc told me to double the dose by mistake and it drugged me into the ground... I stopped taking it after that... Link to comment Share on other sites More sharing options...
4ao Posted July 2, 2011 Author Share Posted July 2, 2011 (edited) ... On 6/28/2011 at 5:32 AM, dogsfoot said: ... Edited February 20, 2020 by 4ao Link to comment Share on other sites More sharing options...
Anna Posted July 2, 2011 Share Posted July 2, 2011 um dogsfoot, I highly doubt that seroquel actually almost killed you, unless you were drug to the er, and told that your heart stopped and you saw the white light or the tunnel and etc. more likely, it completely knocked you out, sleepwise, which sometimes happens. please, no fear mongering about perfectly acceptable medications. Anna Link to comment Share on other sites More sharing options...
Furious George Posted July 2, 2011 Share Posted July 2, 2011 I've been on the regular Seroquel for about 4 years. It has been a wonderful drug for me. I'm not quite sure if it was therapeutic at my dose (100mg), but it definitely got me on a regular sleep cycle. Maybe the proper sleep was more important than its anti-psychotic properties? I think the lack of sleep was making me psychotic. Either way, it has definitely been a winner in my med cocktail. Link to comment Share on other sites More sharing options...
enlightened_plutonian Posted July 2, 2011 Share Posted July 2, 2011 I've been on the regular Seroquel for about 4 years. It has been a wonderful drug for me. I'm not quite sure if it was therapeutic at my dose (100mg), but it definitely got me on a regular sleep cycle. Maybe the proper sleep was more important than its anti-psychotic properties? I think the lack of sleep was making me psychotic. Either way, it has definitely been a winner in my med cocktail. Sleep deprivation brings out my psychosis too. I always tend to hallucinate more when I haven't slept, with all the consequences. And yeah, at 100mg you will probably only get sedation. Link to comment Share on other sites More sharing options...
4ao Posted July 4, 2011 Author Share Posted July 4, 2011 (edited) ... Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
Anna Posted July 4, 2011 Share Posted July 4, 2011 You will find your sweet spot for sleep. Mine is 300 mg which is high, but also the dose to aid depression, and I smoke like a chimney which affects seroquel clearance. Other things that interact: grapefruit juice. Rule of thumb: if you drink it, don't stop, but if you don't do not start. grapefruit juice makes quel hang around longer in your system..... For me, the sedative effects of quel have never worn off, and I've been taking it for years..... You'll probably be good. most people don't report tolerance and lack of sedation, though it does happen occasionally. For sleep, anywhere in the 25--150 or so range seems to be the NORM for people, but everyone responds differently. It can be one of those weird meds where if you go too high on it, you don't feel sleepy at all. but that doesn't happen for me, hah. I'm on 800 of quel now (mixed episode) and I still get very very sleeeeppppyyyy. so yeah, just keep tweaking until you are good. If you do get to the adjunct for depression dose of quel (300 and above, I believe) you may indeed adjust your lamictal levels, but honestly, if it's not broke, don't fix it, etc. Anna Link to comment Share on other sites More sharing options...
4ao Posted July 5, 2011 Author Share Posted July 5, 2011 (edited) ... Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
4ao Posted July 13, 2011 Author Share Posted July 13, 2011 (edited) ..., Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
4ao Posted July 28, 2011 Author Share Posted July 28, 2011 (edited) .... Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
jt07 Posted July 28, 2011 Share Posted July 28, 2011 Crow66, I am truly happy that you found some relief and are feeling better. It gives hope to the rest of us still struggling. Link to comment Share on other sites More sharing options...
4ao Posted August 4, 2011 Author Share Posted August 4, 2011 (edited) ..., Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
4ao Posted August 15, 2011 Author Share Posted August 15, 2011 (edited) ..... Edited February 19, 2020 by 4ao Link to comment Share on other sites More sharing options...
Hooker Posted August 15, 2011 Share Posted August 15, 2011 I take Seroquel XR, 100mg in one dose at night. Although it's effective, I can feel it wearing out late afternoon the next day. I would take it every twelve hours if it weren't for the damn sedating effects. If you can deal with that, spread out your doses. Link to comment Share on other sites More sharing options...
enlightened_plutonian Posted August 15, 2011 Share Posted August 15, 2011 Crow66, I am really glad that you have found a medication that is working for you. Link to comment Share on other sites More sharing options...
MELSTRAUB Posted January 8, 2014 Share Posted January 8, 2014 (edited) I HAVE BEEN ON THE SAME DOSE OF SEROQUEL XR FOR MORE THAN 3 YEARS. IM AT 50 MG. AND I SAW ON HERE THAT YOU CAN TAKE THE XR IN THE AM AND IN THE PM? CUZ I AM THINKING I NEED TO DO THIS WITH MY DOCTORS APPROVAL OF COURSE..HAS ANYONE HAD A GOOD RESULT WITH THIS DOSE? OR SPLTTING DOSES IN THE AM AND PM? REMEMBER THIS IS THE XR 50 MG Edited January 8, 2014 by MELSTRAUB Link to comment Share on other sites More sharing options...
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