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Latuda, According to Wikipedia, Works Better at Treating Negative Symptoms?


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From http://en.wikipedia.org/wiki/Lurasidone

In clinical studies, lurasidone alleviates both positive (e.g., hallucinations, delusions) and negative (e.g., apathy, emotional withdrawal) symptoms of schizophrenia without inducing extrapyramidal side effects except for akathisia, despite its potent D2 antagonistic actions.[4][5]

Lurasidone may be useful for treating cognitive and memory deficits seen in schizophrenia for several reasons: 1) unlike many other antipsychotics, lurasidone does not block the muscarinic acetylcholine receptors, an action well-known to impair learning and memory; 2) lurasidone has prominent activity at 5-HT1A, 5-HT2A, 5-HT7, and α2C-adrenergic receptors, all of which have been implicated in enhancement of cognitive function if modulated properly; 3) due to its low liability for extrapyramidal symptoms, lurasidone is unlikely to require coadministration of anticholinergics, which impair cognition in their own right.[4][5] In animal studies, lurasidone was found to be superior to all of the other antipsychotics examined in reversing dizocilpine-induced learning and memory impairment, including risperidone, olanzapine, quetiapine, clozapine, aripiprazole, and haloperidol.[4][6]

I'm going to ask my Psychiatrist about this med.

What exactly is dizocilpine?

Is Latuda effective in and of itself at treating negative symptoms? I mean, excluding the effects of anticholinergics that are prescribed alongside other antipsychotics.

I really am having a hard time with negative and cognitive symptoms, so I hope this works for that.

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I believe dizocilpine is a drug given to animals to mimic schzophrenia when testing drugs.

I can't say anything about Latuda from first hand experience, but I think that Latuda is worth investigating for you.

Thanks.

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