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Can Benadryl interfere with my meds?

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Hi guys

I had a bit of a breakdown today, flipflop in my mind. Felt like I went form Dr. Jekyl to Mr. hyde within an hour. It was disturbing. I had a panic attack while I was in traffic. Haven't had a panic attack in a long long time. Talking year and a half, however I used to have them all the time.

The only thing I did differently was take a benadryl early morning and this happened this afternoon.

Could be unrelated, wondering if anyone else has had a reaction like this. Thinking the benadryl may have played a trick on my mind. Sometimes mental changes cause me to panic.

I'm on 300mg Effexor XR 50mg Seroquel .5 ativan

Thank you for your time.

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Benadryl makes most people sleepy, but it can have a paradoxical effect in some people. Like my son. You give him benadryl he is AWAKE man. So yes, I do find benadryl to be psychoactive under certain circumstances. Is this the first time you have taken it? The first time you have taken it with meds?


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  • 3 months later...

Are you in the US or the UK?

In the US, Benadryl contains diphenhydramine, the same as Piriton. In most people it's quite sedating, but a few people find it makes them more alert.

In the UK, Benadryl contains acrivastine, which is a whole different kettle of fish. As well as being an antihistamine, it's an opiate potentiator - so it speeds up / boosts the effect of any opioid painkillers you're on. If it can do that, I daresay it also affects other medications, but I can't really remember how.

It's worth talking over with your doctor which antihistamine he/she feels would be least likely to affect your other meds.

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  • 2 months later...

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