ManWitPlan Posted October 20, 2011 Share Posted October 20, 2011 I was on risperdal for 5 years and gained about 125 pounds. Yet I never had diabetes just minor cholesterol issues. Then my doctor added zyprexa and my good cholesterol went way down and bad cholesterol up and my blood sugars went way up and had diabetes till i stopped that med. My question is if I managed my weight while on zyprexa would that prevent the metabolic problems or would I still get them even with diet and exercise and controlled weight? Link to comment Share on other sites More sharing options...
dedoubt Posted October 20, 2011 Share Posted October 20, 2011 I know one person that got Type 1 diabetes from Zyprexa without gaining any weight at all. I know that Zyprexa is one that might have more problems like that regardless of whether you gain weight or not. Talk to your pdoc about it. Link to comment Share on other sites More sharing options...
Velvet Elvis Posted October 20, 2011 Share Posted October 20, 2011 No, zyprexa is famous for this. There have been multimillion dollar class action lawsuits against Eli Lilly because of it giving people diabetes and it's still in use, probably because it works really well as a last resort med for a lot of people. Here's an article on exactly what Z. does to you: http://thelastpsychiatrist.com/2010/10/zyprexa_and_fat.html Link to comment Share on other sites More sharing options...
dedoubt Posted October 20, 2011 Share Posted October 20, 2011 Heh. Multimillion divided by the thousands of people in the suits, and my friend got $5,000. And a lifetime of diabetes. Link to comment Share on other sites More sharing options...
ManWitPlan Posted October 22, 2011 Author Share Posted October 22, 2011 No, zyprexa is famous for this. There have been multimillion dollar class action lawsuits against Eli Lilly because of it giving people diabetes and it's still in use, probably because it works really well as a last resort med for a lot of people. Here's an article on exactly what Z. does to you: http://thelastpsychi...xa_and_fat.html So what are your thoughts on rispderdal/invega? I have a couple questions about that drug. One is why do they say invega is like haldol? Also as far as metabolic syndrome doesn't invega only cause blood glucose levels to rise and not the triglycerides and other blood levels to rise? And for that reason if both invega and zyprexa work it would be best to choose the invega? Because invega worked well for me and i'm thinking I might be better off on invega than symbyax considering invega only effects blood glucose according to the link below/ previous experience. http://www.psychresidentonline.com/atypical%20antipsychotics.htm Link to comment Share on other sites More sharing options...
Anna Posted October 23, 2011 Share Posted October 23, 2011 I would stay on the med that gives you the least side effects, personally. My metabolic profile is shitty, and I take glucophage for it. As well as a cholestorol med. Invega and risperdal are considered "haldol lite" I'm not sure why, I think they were derived from that med somehow, IIRC. Risperdal is the oldest of the AAPs, rather than being an AP. It is also the med that works best to control my sx. Come to think, it may be the one fucking with my metabolic profile rather than anything else, as it used to be quite fine on JUST seroquel, so I don't know. Everyone is different. That said, I'd rather have stability than the greatest health profile which can be treated. If blood glucose and weight gain is a problem, there are some studies about the fact that glucophage (metformin) can reduce this problem in AAPs, generally. It might be worth some googling, they're easy studies to find. Psycheducation.org also has a good page on this med, with links to the studies. I find glucophage to be effective, it caused weight loss and my sugars are great. There is some later research to indicate that taking it BEFORE one's pancreas burns out completely with pre-diabetes is better than waiting, so I really pushed my pdoc for it, and I'm glad I did. Anna Link to comment Share on other sites More sharing options...
ManWitPlan Posted October 23, 2011 Author Share Posted October 23, 2011 I would stay on the med that gives you the least side effects, personally. My metabolic profile is shitty, and I take glucophage for it. As well as a cholestorol med. Invega and risperdal are considered "haldol lite" I'm not sure why, I think they were derived from that med somehow, IIRC. Risperdal is the oldest of the AAPs, rather than being an AP. It is also the med that works best to control my sx. Come to think, it may be the one fucking with my metabolic profile rather than anything else, as it used to be quite fine on JUST seroquel, so I don't know. Everyone is different. That said, I'd rather have stability than the greatest health profile which can be treated. If blood glucose and weight gain is a problem, there are some studies about the fact that glucophage (metformin) can reduce this problem in AAPs, generally. It might be worth some googling, they're easy studies to find. Psycheducation.org also has a good page on this med, with links to the studies. I find glucophage to be effective, it caused weight loss and my sugars are great. There is some later research to indicate that taking it BEFORE one's pancreas burns out completely with pre-diabetes is better than waiting, so I really pushed my pdoc for it, and I'm glad I did. Anna Thanks for the response. I am currently just taking the symbyax for now. That said it did give me diabetes pretty quickly(when i was on it last year) and when on risperdal/invega i only had slightly elevated sugars and elevated liver enzymes. So invega didn't have as much effect as risperdal for you? My doc told me they were basically the same thing with invega being an extended release version.I can't remember if invega worked differently for me than risperdal. Also I was wondering what you use neurontin for. Is it for akathisia? Because I used it before and trying to figure out what new meds i should ask for with my next doc visit coming dec 3rd. So far i'm thinking that I should switch off of zyprexa and go on invega and saphris and use neurontin for akathisia. Also does metformin work for liver enzymes? cause thats what i might need help with also. Link to comment Share on other sites More sharing options...
Anna Posted October 24, 2011 Share Posted October 24, 2011 No metformin will not work for liver enzymes. If they are elevated, you need to be getting that checked out, like, seriously. Neurontin is not for akathesia, and to my knowledge does not work for that purpose. I use it to boost my main mood stabilizer and have found it to be helpful with generalized anxiety for the most part when I'm not episodic, which is why I take it. I've only ever been on it at all because it was given to me during the snake oil days when neurontin salesmen were stating it cured bp and a whole host of other conditions when it really doesn't. It's an ineffective mood stabilizer but does have some benefit as an add on medication. Things neurontin can be helpful with, to my knowledge: anxiety, neuropathic pain, depression (maybe) sleep (maybe) add on to a real mood stabilizer (sort of, maybe). I do do better on it than off it, overall, so I keep taking it as it gives me no side effects. For akathesia you are looking at benadryl, cogentin, or benzos, really. Anna Link to comment Share on other sites More sharing options...
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