BouncingMind Posted December 18, 2011 Share Posted December 18, 2011 http://www.democrati...ddress=222x1095 I don't know what to make of this. This sounds scary. i mean that sounds like a recipe for reducing dopamine...its even scarier to think its mixing em up like a scary soupbowl with two different vegetables. damn...why can't these meds ever be simple. Edit: damn i didnt read the full article. apparently this also increases dopamine and serotonin in rewarding parts of the brain...hence its a good thing. Link to comment Share on other sites More sharing options...
crtclms Posted December 18, 2011 Share Posted December 18, 2011 Political websites are not the best source for information on neurotransmitters. Link to comment Share on other sites More sharing options...
Cetkat Posted December 19, 2011 Share Posted December 19, 2011 Well, the political site links to this: http://www.news-medi...04/06/9041.aspx of which I was able to track down the study they're talking about. Dopamine and serotonin crosstalk within the dopaminergic and serotonergic systems. Zhou, Fu-Ming; Dani, John A.. In Co-existence and co-release of classical neurotransmitters: Ex uno plures, edited by Gutiérrez, Rafael, 145-180. New York, NY, US:Springer Science + Business Media, 2009. Dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) fibers broadly innervate the brain. DA transporters (DATs) and 5-HT transporters (SERTs) determine the temporal and spatial extent of the signals, but the transporters are not completely selective. Under circumstances that elevate extracellular 5-HT (such as treatment with antidepressants that block SERTs), DATs expressed on the dense DA terminals of the striatum uptake 5-HT. Subsequently, 5-HT enters DA synaptic vesicles, and DA and 5-HT are co-released. Circumstances also can favor DA loading into 5-HT neurons and terminals. For example, during L-dopa treatment of Parkinson's disease, 5-HT neurons uptake L-dopa that is subsequently converted to DA, leading to corelease. DA and 5-HT neurons promiscuously uptake each other's neurotransmitter and co-release occurs under certain conditions. This process induces DA and 5-HT co-signaling mechanisms that have important implications for neuropsychiatric disorders and their treatments. (PsycINFO Database Record © 2010 APA, all rights reserved) The actual study isn't available online for me. Link to comment Share on other sites More sharing options...
Closure Posted December 20, 2011 Share Posted December 20, 2011 I do not think that that study, just from the direction that abstract is going, is something that the normal member of the public is going to have the least ability to understand, and that news-medical.net article in turn seems to be taking what is more likely basic research and then distorting it greatly while playing to preexisting fears amongst various parts of the public about psychiatric meds. Towards the end of the article the author seems to just throwing out random thoughts of theirs, while clearly showing that they are just playing up such fears by conflating serotonin syndrome (which is truly not a threat with antidepressants unless combined with certain kinds of other meds or drugs) with dietary restrictions imposed by MAOIs (which obviously tend to be treated as a last resort today). In short, the article is obviously a piece of garbage, and there are certainly much better analyses of this study out there than this. Link to comment Share on other sites More sharing options...
Cetkat Posted December 20, 2011 Share Posted December 20, 2011 In short, the article is obviously a piece of garbage, and there are certainly much better analyses of this study out there than this. I'm not making any claims about the analysis. Only showing how I reached the actual study and pointing to where the OP's site was obtaining their information. I listed them as a means for others to do their own research and independent assessment should they choose. Link to comment Share on other sites More sharing options...
Closure Posted December 20, 2011 Share Posted December 20, 2011 In short, the article is obviously a piece of garbage, and there are certainly much better analyses of this study out there than this. I'm not making any claims about the analysis. Only showing how I reached the actual study and pointing to where the OP's site was obtaining their information. I listed them as a means for others to do their own research and independent assessment should they choose. I knew you were not. Link to comment Share on other sites More sharing options...
Cetkat Posted December 20, 2011 Share Posted December 20, 2011 In short, the article is obviously a piece of garbage, and there are certainly much better analyses of this study out there than this. I'm not making any claims about the analysis. Only showing how I reached the actual study and pointing to where the OP's site was obtaining their information. I listed them as a means for others to do their own research and independent assessment should they choose. I knew you were not. Ok. Just wanted to clarify. Link to comment Share on other sites More sharing options...
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