SpartanForce Posted March 11, 2012 Share Posted March 11, 2012 Which one is better for sexual dysfunction? "SSRIs can cause various types of sexual dysfunction such as anorgasmia, erectile dysfunction, and diminished libido. Initial studies found sexual side effects not significantly different from placebo, but since these studies relied on unprompted reporting, the frequency was probably underestimated. In more recent studies, doctors have specifically asked about sexual difficulties, and found that they are present in between 17% and 41%[23][24] of patients, although the lack of placebo control in these studies means they are likely overestimates. Stimulation of postsynaptic 5-HT2 and 5-HT3 receptors decreases dopamine and norepinephrine release from the substantia nigra. A number of drugs are not associated with sexual side effects. As a result, sexual dysfunction caused by SSRIs can sometimes be mitigated by several different drugs. These include:buspirone (serotonin 5-HT1A receptor partial agonist)mirtazapine (noradrenergic and specific serotonergic antidepressant (NaSSA))pramipexole (dopamine agonist) andropinirole (dopamine agonist) On the other hand, the effect of SSRIs to slow down sexual stimulation may be used as treatment; SSRIs have been proposed as a drug to treat premature ejaculation." Link to comment Share on other sites More sharing options...
jt07 Posted March 11, 2012 Share Posted March 11, 2012 Are you asking which med is best to add to your SSRI to mitigate sexual dysfunction? I think you just have to try them to find out because like all psych meds, it is very individual. Usually the first-line addition is Wellbutrin, but Wellbutrin never did anything for me. Remeron (mirtazapine) works for me though. And Abilify really increased my libido, but I can no longer handle it psychologically. Link to comment Share on other sites More sharing options...
kittyloaf Posted March 11, 2012 Share Posted March 11, 2012 I have read anecdotal evidence that Wellbutrin can increase libido. It's no guarantee though. Link to comment Share on other sites More sharing options...
otherwise the curved Posted March 11, 2012 Share Posted March 11, 2012 Wellbutrin has the best reputation, but it completely depends on the person. I'm taking Pristiq, and my sex drive hasn't dropped (and it usually disappears with most anti-d's). otc Link to comment Share on other sites More sharing options...
SpartanForce Posted March 12, 2012 Author Share Posted March 12, 2012 From the four only, wellbutrin I already tried and it was a no-go. Link to comment Share on other sites More sharing options...
chimpmaster Posted March 17, 2012 Share Posted March 17, 2012 Rermon (mirtazapine) is reputed to having the best sexual side effect profile of the drugs you mentioned. Wellbutrin also has a great rep, but you already tried that one. Link to comment Share on other sites More sharing options...
Guest Vapourware Posted March 17, 2012 Share Posted March 17, 2012 A few things: a) Everyone's responses to medication is different. The only way you're going to find out about whether a drug impacts on you sexually is by taking it. Frustrating? Yes. However, that is just how things are. b) Wikipedia is NOT a definitive source of information. c) Stop trying to play doctor on yourself and TALK TO YOUR DOCTOR, since they've had years of professional training in medicine. Link to comment Share on other sites More sharing options...
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